Souza Sávio Reder de, Azulay-Abulafia Luna, Nascimento Leninha Valério do
Pedro Ernesto Teaching Hospital, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
An Bras Dermatol. 2011 Mar-Apr;86(2):284-91. doi: 10.1590/s0365-05962011000200012.
Pemphigus vulgaris is a severe bullous disease, produced by the autoimmune destruction of desmosomes, resulting in the formation of intraepidermal blisters, affecting skin and mucous membranes, with a mortality of 5 to 10%. Side effects of therapy contributed to increased morbidity, accounting for considerable part of the immediate causes of death due to PV today. There is no reproducible score for clinical evaluation of patients with Pemphigus vulgaris, making the therapeutic decision subjective, and its results, uncertain.
Create and evaluate the reproducibility of a scoring system for clinical evaluation of patients with pemphigus vulgaris.
The Commitment Index of Skin and Mucous in Pemphigus Vulgaris was created, scoring easily observed findings on clinical examination. During 3 years, 7 patients with active PV were submitted to pairings of Commitment Index of Skin and Mucous in Pemphigus Vulgaris conduced by independent examiners for determinate its reproducibility.
The Commitment Index of Skin and Mucous in Pemphigus Vulgaris proved that it is reproducible in all the statistical methods used to assess agreement between the independent examiners. In adition, it permited us to separate the patients into classes of severity.
The Commitment Index of Skin and Mucous in Pemphigus Vulgaris can classify the severity of Pemphigus Vulgaris, contributing to medical research, and to the standardization of the therapy in the near future.
寻常型天疱疮是一种严重的大疱性疾病，由桥粒的自身免疫性破坏引起，导致表皮内水疱形成，累及皮肤和黏膜，死亡率为5%至10%。治疗的副作用导致发病率增加，在当今寻常型天疱疮直接死亡原因中占相当大的比例。目前尚无用于寻常型天疱疮患者临床评估的可重复评分系统，这使得治疗决策具有主观性，其结果也不确定。
创建并评估一种用于寻常型天疱疮患者临床评估的评分系统的可重复性。
创建了寻常型天疱疮皮肤和黏膜受累指数，对临床检查中易于观察到的结果进行评分。在3年时间里，7例活动性寻常型天疱疮患者由独立检查者进行寻常型天疱疮皮肤和黏膜受累指数配对，以确定其可重复性。
寻常型天疱疮皮肤和黏膜受累指数在用于评估独立检查者之间一致性的所有统计方法中均证明具有可重复性。此外，它使我们能够将患者分为不同的严重程度类别。
寻常型天疱疮皮肤和黏膜受累指数可以对寻常型天疱疮的严重程度进行分类，有助于医学研究，并在不久的将来实现治疗的标准化。
