Department of Dermatology, Westmead Hospital, Westmead, Sydney, NSW, Australia.
Immunol Allergy Clin North Am. 2012 May;32(2):233-43, v-vi. doi: 10.1016/j.iac.2012.04.003.
Autoimmune bullous diseases are associated with autoimmunity against structural components that maintain cell-cell and cell-matrix adhesion in the skin and mucous membranes. They include those where the skin blisters at the basement membrane zone and those where the skin blisters within the epidermis (pemphigus vulgaris, pemphigus foliaceus, and other subtypes of pemphigus). The variants of pemphigus are determined according to the level of intraepidermal split formation. There are 5 main variants of pemphigus: pemphigus vulgaris, pemphigus foliaceus, pemphigus erythematosus, drug-induced pemphigus, and paraneoplastic pemphigus. This review focuses only on pemphigus vulgaris.
自身免疫性大疱性疾病与针对维持皮肤和黏膜细胞-细胞和细胞-基质黏附的结构成分的自身免疫有关。它们包括基底膜带处皮肤起疱的疾病和表皮内皮肤起疱的疾病（寻常型天疱疮、落叶型天疱疮和其他类型的天疱疮）。天疱疮的变体根据表皮内分裂形成的水平来确定。天疱疮有 5 种主要变体：寻常型天疱疮、落叶型天疱疮、红斑型天疱疮、药物诱导性天疱疮和副肿瘤性天疱疮。本综述仅关注寻常型天疱疮。
