Biology Division, Department of Biological, Chemical, and Physical Sciences, Illinois Institute of Technology, Chicago, IL, USA.
Biotechnol Lett. 2011 Sep;33(9):1705-14. doi: 10.1007/s10529-011-0621-9. Epub 2011 May 21.
The hemoglobin from the bacterium Vitreoscilla (VHb) is the first microbial hemoglobin that was conclusively identified as such (in 1986). It has been extensively studied with respect to its ligand binding properties and mechanisms, structure, biochemical functions, and the mechanisms by which its expression is controlled. In addition, cloning of its gene (vgb) into a variety of heterologous hosts has proved that its expression results substantial increases in production of a variety of useful products and ability to degrade potentially harmful compounds. Recent studies (since 2005) have added significant knowledge to all of these areas and shown the broad range of biotechnological applications in which VHb can have a positive effect.
来自细菌威斯塔耳（Vitreoscilla）的血红蛋白（VHb）是第一个被明确鉴定为微生物血红蛋白的血红蛋白（1986 年）。已经对其配体结合特性和机制、结构、生化功能以及其表达调控机制进行了广泛的研究。此外，将其基因（vgb）克隆到各种异源宿主中已证明其表达可显著提高多种有用产品的产量，并提高降解潜在有害物质的能力。自 2005 年以来的最新研究为所有这些领域增加了重要的知识，并展示了 VHb 可以在其中产生积极影响的广泛生物技术应用。
