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钌催化的羧酸对取代芳基和三氟甲基取代的不对称内部炔烃的区域和立体选择性加成。

Ruthenium-catalyzed regio- and stereoselective addition of carboxylic acids to aryl and trifluoromethyl group substituted unsymmetrical internal alkynes.

机构信息

Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Koyama, Tottori 680-8552, Japan.

出版信息

Org Lett. 2011 Jun 17;13(12):3285-7. doi: 10.1021/ol201238u. Epub 2011 May 23.

DOI:10.1021/ol201238u
PMID:21604776
Abstract

The regio- and stereoselective addition of carboxylic acids to aryl and trifluoromethyl group substituted unsymmetrical internal alkynes has been accomplished: the Ru(3)(CO)(12)/3PPh(3) catalyst system has effectively catalyzed the reaction to afford the trifluoromethyl group substituted (E)-enol esters with high regio- and stereoselectivities.

摘要

已完成羧酸对取代的芳基和三氟甲基基团的不对称内炔的区域和立体选择性加成

Ru(3)(CO)(12)/3PPh(3)催化剂体系有效地催化了反应，以高区域和立体选择性得到三氟甲基取代的（E）-烯醇酯。

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