Evans G H, Weaver C M, Harrington D D, Babbs C F
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907.
J Hypertens. 1990 Apr;8(4):327-37. doi: 10.1097/00004872-199004000-00006.
The role of dietary calcium and magnesium in the development of hypertension was studied in nine groups, each consisting of nine spontaneously hypertensive rats aged 8-31 weeks. The animals were fed AIN 76A semi-purified diets varying in calcium (0.075, 0.5 and 2.5%) and magnesium (0.01, 0.05 and 0.75%) concentrations according to a 3 x 3 factorial design. Dietary calcium and systolic blood pressure were inversely related, significantly (P less than 0.05) after 12 weeks. Total and ultrafilterable serum calcium concentrations were also significantly negatively correlated with blood pressure (r = -0.46; P = 0.001 and r = -0.57; P = 0.001, respectively). Repeated measures analysis of variance indicated that dietary magnesium had no effect on systolic blood pressure, and no calcium x magnesium interaction on blood pressure was observed. Signs of magnesium deficiency, calcium deposits in the kidneys, and histological lesions were observed in groups on a high-calcium diet receiving normal and low levels of magnesium. Thus a lowering of blood pressure by calcium supplementation, without concomitant magnesium supplementation, was accompanied by biochemical and histological abnormalities in this animal model.
在九个组中研究了膳食钙和镁在高血压发展中的作用，每组由九只8 - 31周龄的自发性高血压大鼠组成。根据3×3析因设计，给动物喂食钙（0.075%、0.5%和2.5%）和镁（0.01%、0.05%和0.75%）浓度不同的AIN 76A半纯化日粮。膳食钙与收缩压呈负相关，12周后具有显著性（P小于0.05）。血清总钙浓度和超滤性钙浓度也与血压显著负相关（分别为r = -0.46；P = 0.001和r = -0.57；P = 0.001）。重复测量方差分析表明，膳食镁对收缩压无影响，未观察到钙与镁对血压的交互作用。在接受正常和低水平镁的高钙饮食组中，观察到了镁缺乏的迹象、肾脏中的钙沉积和组织学病变。因此，在该动物模型中，不补充镁而仅补充钙来降低血压会伴随着生化和组织学异常。
