Wing L M, Nestel P J, Chalmers J P, Rouse I, West M J, Bune A J, Tonkin A L, Russell A E
Hypertension Clinic, Flinders Medical Centre, Bedford Park, Australia.
J Hypertens. 1990 Apr;8(4):339-43. doi: 10.1097/00004872-199004000-00007.
Fish and fish oils have been reported to reduce blood pressure in normotensives and untreated hypertensives. The present study examined the effect of dietary supplementation with fish oil on blood pressure in 20 treated hypertensives with controlled blood pressures who continued their usual antihypertensive drug treatment throughout. A double-blind, randomized crossover design was used, with two phases, each of 8 weeks' duration. In one phase, subjects took fifteen 1 g fish oil capsules (Lipitac; Reckitt and Colman Pharmaceuticals, Sydney, Australia) daily, and in the other, 15 capsules of identical appearance containing 1 g olive oil daily. There was no difference between the treatment phases for any blood pressure parameter, heart rate or body weight, but blood pressure was lower in both phases compared with pretreatment values. The fasting plasma triglyceride concentration was 30% lower in the fish oil phase (P less than 0.001), but there was no difference between the phases for plasma concentrations of total or high-density lipoprotein (HDL) cholesterol. We conclude that, in treated hypertensives with controlled blood pressures, any additional fall in blood pressure produced by dietary supplementation with fish oil is so small that the requirement for antihypertensive drug therapy is unlikely to be reduced.
据报道，鱼类和鱼油可降低血压正常者及未经治疗的高血压患者的血压。本研究调查了在20例血压得到控制的接受治疗的高血压患者中，膳食补充鱼油对血压的影响，这些患者在整个研究过程中持续进行常规降压药物治疗。采用双盲、随机交叉设计，分为两个阶段，每个阶段为期8周。在一个阶段，受试者每天服用15粒1克的鱼油胶囊（Lipitac；澳大利亚悉尼瑞侃和科尔曼制药公司），在另一个阶段，他们每天服用15粒外观相同、含1克橄榄油的胶囊。在任何血压参数、心率或体重方面，治疗阶段之间均无差异，但与治疗前值相比，两个阶段的血压均较低。在鱼油阶段，空腹血浆甘油三酯浓度降低了30%（P<0.001），但在总胆固醇或高密度脂蛋白（HDL）胆固醇的血浆浓度方面，两个阶段之间没有差异。我们得出结论，在血压得到控制的接受治疗的高血压患者中，膳食补充鱼油所产生的额外血压下降幅度很小，不太可能减少对抗高血压药物治疗的需求。
