Renaud Christian, Kuypers Jane, Aspesberro François, Rosenfeld Margaret, Englund Janet A
Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
J Asthma. 2011 Aug;48(6):572-5. doi: 10.3109/02770903.2011.582660. Epub 2011 May 23.
Pandemic influenza A (H1N1) may cause severe illness in pediatric patient with chronic lung disease.
We describe the emergence of oseltamivir resistance in an immunocompetent child with status asthmaticus triggered by pandemic influenza A (H1N1). This case highlights the possible relationship between influenza viral load and risk of resistance emergence in children with asthma. Influenza vaccination should continue to be emphasized as the mainstay of prevention in children with chronic lung disease.
Influenza virus can lead to severe status asthmaticus and can develop oseltamivir resistance in immunocompetent children.
甲型H1N1流感大流行可能会导致患有慢性肺病的儿科患者出现严重疾病。
我们描述了一名免疫功能正常、患有哮喘持续状态的儿童,因甲型H1N1流感大流行引发了对奥司他韦的耐药性。该病例突出了流感病毒载量与哮喘儿童耐药性出现风险之间的可能关系。应继续强调流感疫苗接种是慢性肺病儿童预防的主要手段。
流感病毒可导致严重的哮喘持续状态,并可在免疫功能正常的儿童中产生对奥司他韦的耐药性。