Skin Laser and Surgery Specialists of New York and New Jersey, New York, New York 10022, USA.
Dermatol Surg. 2011 Jun;37(6):784-90. doi: 10.1111/j.1524-4725.2011.01964..x.
To compare the safety and efficacy of two fractional carbon dioxide (CO(2)) laser devices for the treatment of photodamaged facial skin.
Eight healthy subjects underwent full-face resurfacing for photodamaged skin with two fractionated CO(2) laser devices using manufacturer-recommended settings for facial rejuvenation. For each subject, one device with a rolling handpiece was used on one side and a second device with a stamping handpiece was used on the other. Patients were evaluated 3 months postoperatively and photographed. A blinded physician investigator assessed the photographs and rated each side for improvement in four categories (wrinkles, pigmentation, skin laxity, and overall appearance). Patient ratings for overall improvement for each side were also recorded.
All patients had improved on the basis of photographic and clinical assessments at 3 months. No significant differences in patient ratings of overall improvement and physician-measured parameters of clinical improvement were found, although intraoperative times and pain ratings were greater with the laser with the stamping handpiece. No complications were experienced with either device.
Both fractionated CO(2) resurfacing devices used in the study were safe and effective for the treatment of photodamaged facial skin, but the modality using a stamping handpiece was associated with longer operative times and greater intraoperative pain. The authors have indicated no significant interest with commercial supporters.
比较两种用于治疗光老化面部皮肤的分划二氧化碳（CO 2 ）激光设备的安全性和疗效。
8 名健康受试者使用制造商推荐的面部年轻化设置，用两种分划 CO 2 激光设备对光老化的全脸皮肤进行全面换肤。对于每个受试者，使用一个带有滚动手柄的设备对一侧进行治疗，使用另一个带有冲压手柄的设备对另一侧进行治疗。患者在术后 3 个月进行评估并拍照。一位经过盲法培训的医师评估照片，并根据四个类别（皱纹、色素沉着、皮肤松弛和整体外观）对每一侧的改善情况进行评分。还记录了每位患者对每一侧整体改善的评分。
所有患者在术后 3 个月的照片和临床评估基础上均有改善。尽管使用冲压手柄的激光设备的手术时间和疼痛评分更高，但患者对整体改善的评分和医师测量的临床改善参数均无显著差异。两种设备均未出现并发症。
研究中使用的两种分划 CO 2 换肤设备均安全有效，可用于治疗光老化面部皮肤，但使用冲压手柄的模式与较长的手术时间和更大的术中疼痛相关。作者表示与商业支持者没有重大利益关系。
