Mokhtari Fatemeh, Safavi Zahra, Faghihi Gita, Asilian Ali, Shahmoradi Zabihollah
Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Skin and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2023 Apr 25;12:90. doi: 10.4103/abr.abr_330_21. eCollection 2023.
Acne is a dermatologic condition with a high burden in terms of psychosocial consequences as a result of scars remaining on the skin. Its effects are severe in adolescence and finding treatments with short therapy courses, superior results, and fewer adverse effects are of high importance.
We included 30 individuals with acne vulgaris scars in Al-Zahra academic training hospital from June 2018 to Jan 2019. Each individual received both fractional CO and fractional Er:YAG lasers on right and left sides of the face, respectively. Three sessions of laser treatment were applied to each side with one-month intervals. Results were evaluated by patients according to subjective satisfaction and physicians' assessment and photo evaluation by two blinded dermatologists. Improvement was graded by a quartile grading scale: less than 25%: mild, 25% to 50%: moderate, 51% to 75%: good, and 76% to 100%: excellent response. Assessments were obtained at baseline and one month after the last visit.
Based on subjective satisfaction (p < 0.05) and physicians' assessment (p < 0.01), fractional CO laser was significantly more effective than Erbium:YAG laser. Also, Post-treatment side effects were mild and transient in both groups.
Laser therapies are common in the treatment of scars and each modality has special advantages and disadvantages. Choosing among them should be based on various criteria. Fractional CO lasers have been revealed favorable results in most reports. Large comprehensive trials could help experts in choosing among alternatives for different subgroups.
痤疮是一种皮肤病，由于皮肤上留下疤痕，在心理社会后果方面负担沉重。其影响在青春期较为严重，找到疗程短、效果好且副作用少的治疗方法至关重要。
2018年6月至2019年1月，我们纳入了阿尔扎赫拉学术培训医院的30例寻常痤疮疤痕患者。每位患者分别在面部右侧和左侧接受分次二氧化碳激光和分次铒：钇铝石榴石激光治疗。每侧进行三次激光治疗，间隔一个月。患者根据主观满意度、医生评估以及两名盲法皮肤科医生的照片评估来评价结果。改善情况采用四分位数分级量表进行分级：改善小于25%为轻度，25%至50%为中度，51%至75%为良好，76%至100%为极佳反应。在基线和最后一次就诊后一个月进行评估。
基于主观满意度（p < 0.05）和医生评估（p < 0.01），分次二氧化碳激光比铒：钇铝石榴石激光显著更有效。此外，两组治疗后的副作用均轻微且短暂。
激光疗法在疤痕治疗中很常见，每种方式都有其特殊的优缺点。在它们之间进行选择应基于各种标准。大多数报告显示分次二氧化碳激光有良好效果。大型综合试验有助于专家为不同亚组在多种选择中做出抉择。
