Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX37BN, UK.
J Struct Biol. 2011 Aug;175(2):224-9. doi: 10.1016/j.jsb.2011.05.009. Epub 2011 May 14.
The Protein Information Management System (PiMS) is a laboratory information management system (LIMS) designed for use with the production of proteins in a research environment. The software is distributed under the CCP4 licence, and so is available free of charge to academic laboratories. Like most LIMS, the underlying PiMS data model originally had no support for protein-protein complexes. To support the SPINE2-Complexes project the developers have extended PiMS to meet these requirements. The modifications to PiMS, described here, include data model changes, additional protocols, some user interface changes and functionality to detect when an experiment may have formed a complex. Example data are shown for the production of a crystal of a protein complex. Integration with SPINE2-Complexes Target Tracker application is also described.
蛋白质信息管理系统 (PiMS) 是一个实验室信息管理系统 (LIMS)，专为在研究环境中生产蛋白质而设计。该软件根据 CCP4 许可证分发，因此可供学术实验室免费使用。与大多数 LIMS 一样，最初的 PiMS 基础数据模型不支持蛋白质-蛋白质复合物。为了支持 SPINE2-Complexes 项目，开发人员扩展了 PiMS 以满足这些要求。这里描述的 PiMS 修改包括数据模型更改、附加协议、一些用户界面更改以及检测实验是否形成复合物的功能。还展示了用于生产蛋白质复合物晶体的示例数据。还描述了与 SPINE2-Complexes Target Tracker 应用程序的集成。
