Prilusky Jaime, Oueillet Eric, Ulryck Nathalie, Pajon Anne, Bernauer Julie, Krimm Isabelle, Quevillon-Cheruel Sophie, Leulliot Nicolas, Graille Marc, Liger Dominique, Trésaugues Lionel, Sussman Joel L, Janin Joël, van Tilbeurgh Herman, Poupon Anne
Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot 76100, Israel.
Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):671-8. doi: 10.1107/S0907444905001290. Epub 2005 May 26.
Structural genomics aims at the establishment of a universal protein-fold dictionary through systematic structure determination either by NMR or X-ray crystallography. In order to catch up with the explosive amount of protein sequence data, the structural biology laboratories are spurred to increase the speed of the structure-determination process. To achieve this goal, high-throughput robotic approaches are increasingly used in all the steps leading from cloning to data collection and even structure interpretation is becoming more and more automatic. The progress made in these areas has begun to have a significant impact on the more 'classical' structural biology laboratories, dramatically increasing the number of individual experiments. This automation creates the need for efficient data management. Here, a new piece of software, HalX, designed as an 'electronic lab book' that aims at (i) storage and (ii) easy access and use of all experimental data is presented. This should lead to much improved management and tracking of structural genomics experimental data.
结构基因组学旨在通过核磁共振（NMR）或X射线晶体学系统地确定结构，从而建立一个通用的蛋白质折叠字典。为了跟上蛋白质序列数据的爆炸式增长，结构生物学实验室被激励提高结构测定过程的速度。为实现这一目标，高通量机器人方法越来越多地应用于从克隆到数据收集的所有步骤，甚至结构解释也变得越来越自动化。这些领域取得的进展已开始对更“传统”的结构生物学实验室产生重大影响，极大地增加了单个实验的数量。这种自动化产生了对高效数据管理的需求。在此，介绍一款新软件HalX，它被设计为一本“电子实验记录本”，旨在（i）存储以及（ii）方便访问和使用所有实验数据。这将大大改善结构基因组学实验数据的管理和跟踪。
