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Soluble guanylate cyclase as an emerging therapeutic target in cardiopulmonary disease.

作者信息

Stasch Johannes-Peter, Pacher Pál, Evgenov Oleg V

机构信息

Institute of Pharmacy, Martin Luther University, Halle, and the Cardiology Research, Bayer HealthCare AG, Wuppertal, Germany.

出版信息

Circulation. 2011 May 24;123(20):2263-73. doi: 10.1161/CIRCULATIONAHA.110.981738.

DOI:10.1161/CIRCULATIONAHA.110.981738
PMID:21606405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103045/
Abstract
摘要

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Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure.西那卡塞，一种可溶性鸟苷酸环化酶激活剂，在急性失代偿性心力衰竭中不仅能减轻心脏负荷，还会引起低血压。
Eur Heart J. 2013 Jan;34(1):57-67. doi: 10.1093/eurheartj/ehs196. Epub 2012 Jul 9.
2
Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.肺和全身血管扩张对可溶性鸟苷酸环化酶激活剂 BAY 60-2770 的反应不依赖于内源性一氧化氮或还原血红素。
Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H792-802. doi: 10.1152/ajpheart.00953.2010. Epub 2011 Jan 7.
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Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1141-58. doi: 10.1152/ajpheart.00767.2010. Epub 2011 Jan 7.
4
Long-term oral treatment with BAY 41-2272 ameliorates impaired corpus cavernosum relaxations in a nitric oxide-deficient rat model.长期口服 BAY 41-2272 可改善一氧化氮缺乏型大鼠模型的海绵体平滑肌松弛功能障碍。
BJU Int. 2011 Jul;108(1):116-22. doi: 10.1111/j.1464-410X.2010.09776.x. Epub 2010 Oct 15.
5
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Nat Rev Cardiol. 2010 Nov;7(11):648-59. doi: 10.1038/nrcardio.2010.144. Epub 2010 Oct 5.
6
BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats.BAY 41-2272 抑制大鼠慢性低氧性肺动脉高压的发展。
Eur J Pharmacol. 2010 Nov 25;647(1-3):147-54. doi: 10.1016/j.ejphar.2010.08.032. Epub 2010 Sep 7.
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Riociguat (BAY 63-2521) and warfarin: a pharmacodynamic and pharmacokinetic interaction study.利奥西呱（BAY 63-2521）与华法林：药效学和药代动力学的相互作用研究。
J Clin Pharmacol. 2011 Jul;51(7):1051-60. doi: 10.1177/0091270010378119. Epub 2010 Aug 27.
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Cinaciguat, a soluble guanylate cyclase activator for the potential treatment of acute heart failure.西那吉特，一种用于急性心力衰竭潜在治疗的可溶性鸟苷酸环化酶激活剂。
Curr Opin Investig Drugs. 2010 Sep;11(9):1039-47.
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J Hypertens. 2010 Aug;28(8):1666-75. doi: 10.1097/HJH.0b013e32833b558c.