Yan Bing Ju, Zhang Jing, Wang Jun, Yuan Hong Xia
Department of Cardiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Front Pharmacol. 2025 Jun 10;16:1501330. doi: 10.3389/fphar.2025.1501330. eCollection 2025.
The stimulation and activation of soluble guanylate cyclase (sGC) has been a prominent focus of study in recent years. Currently, sGC stimulators/activators have a wide range of applications in various fields. However, there remains a gap in bibliometric analysis on this topic. We aim to visualize the research hotspots and trends in the field of sGC stimulators or activators. This analysis can equip researchers to understand current findings and forecast future trends efficiently.
The researchers searched for publications on sGC stimulators or activators in Web of Science Core Collection (WoSCC) on 22 July 2024. We then organized and analyzed the data using Microsoft Excel, online tool (Weishengxin), R, VOS viewer, and CiteSpace.
1,879 papers from WoSCC were gathered for analysis, comprising 1,582 articles and 297 reviews. The United States is the most productive country. And Germany stands out as the country with the most robust collaboration. The most productive institution is BAYER AG. Furthermore, the majority of journals with citation frequencies in the top 10 belong to Q1. The Professor Stasch, JP is the most prolific author and the top co-cited author. Currently, the influential keywords include "riociguat", "outcome", "guanylate cyclase stimulator", "heart failure", "natriuretic peptide", "vericiguat", "reduced ejection fraction", "mortality" and "placebo".
The future research hotspots will focus on the following aspects based on the current research hotspots: the safety verification of riociguat, the clinical efficacy of vericiguat for other types of heart failure, the role of praliciguat in diabetes nephropathy, and the efficacy and safety of newly discovered drugs. Furthermore, actively exploring new therapeutic directions for sGC stimulators or activators may also be an important trend in the future development of this field.
可溶性鸟苷酸环化酶（sGC）的刺激与激活是近年来研究的一个突出重点。目前，sGC刺激剂/激活剂在各个领域有着广泛应用。然而，关于这一主题的文献计量分析仍存在空白。我们旨在可视化sGC刺激剂或激活剂领域的研究热点与趋势。该分析能够使研究人员有效地了解当前研究成果并预测未来趋势。
研究人员于2024年7月22日在科学网核心合集（WoSCC）中搜索关于sGC刺激剂或激活剂的出版物。然后，我们使用Microsoft Excel、在线工具（微生信）、R、VOS viewer和CiteSpace对数据进行整理与分析。
从WoSCC收集了1879篇论文用于分析，其中包括1582篇文章和297篇综述。美国是产出最多的国家。德国是合作最为活跃的国家。产出最多的机构是拜耳公司。此外，被引频次排名前十的期刊大多属于Q1区。施塔施教授（JP）是发文量最多的作者以及被引频次最高的共同作者。目前，有影响力的关键词包括“利奥西呱”“结局”“鸟苷酸环化酶刺激剂”“心力衰竭”“利钠肽”“维立西呱”“射血分数降低”“死亡率”和“安慰剂”。
基于当前研究热点，未来研究热点将集中在以下几个方面：利奥西呱的安全性验证、维立西呱对其他类型心力衰竭的临床疗效、普拉西呱在糖尿病肾病中的作用以及新发现药物的疗效与安全性。此外，积极探索sGC刺激剂或激活剂的新治疗方向也可能是该领域未来发展的一个重要趋势。
