孕激素水平可预测男性人类大脑中 5-羟色胺 1a 受体结合。
Progesterone level predicts serotonin-1a receptor binding in the male human brain.
机构信息
Departments of Psychiatry and Psychotherapy, Medical University of Vienna, Austria. rupert.lanzenberger @ meduniwien.ac.at
出版信息
Neuroendocrinology. 2011;94(1):84-8. doi: 10.1159/000328432. Epub 2011 May 21.
BACKGROUND
Progesterone (P) is thought to influence mood and affective states. Alterations of the inhibitory serotonin-1A (5-HT(1A)) receptor distribution are associated with depression and anxiety. This study evaluates the influence of plasma P levels on the 5-HT(1A) receptor binding in healthy male subjects.
METHODS
Molecular neuroimaging of the 5-HT(1A) receptor distribution using positron emission tomography and hormone assays for total plasma P and cortisol were done in a sample of 18 healthy men.
RESULTS
Plasma P levels explained up to 65% of the variability in 5-HT(1A) receptor binding in limbic regions including the amygdala, orbitofrontal cortex and retrosplenial cortex. When controlling for cortisol in the model, there was an expected decline in explained variances of 5-HT(1A) binding attributed to P.
CONCLUSIONS
The results of this study provide further support for the effect of P on 5-HT(1A) receptor expression and raise the possibility that P mediates the vulnerability to mood disorders by affecting the serotonergic system.
背景
孕激素（P）被认为会影响情绪和情感状态。抑制性 5-羟色胺 1A（5-HT1A）受体分布的改变与抑郁和焦虑有关。本研究评估了健康男性受试者血浆 P 水平对 5-HT1A 受体结合的影响。
方法
使用正电子发射断层扫描对 5-HT1A 受体分布进行分子神经影像学研究，并对总血浆 P 和皮质醇进行激素检测，共纳入 18 名健康男性。
结果
血浆 P 水平可解释包括杏仁核、眶额皮质和后扣带回皮质在内的边缘区域 5-HT1A 受体结合的 65%的可变性。当模型中控制皮质醇时，归因于 P 的 5-HT1A 结合的可解释方差预计会下降。
结论
本研究结果进一步支持 P 对 5-HT1A 受体表达的影响，并提出 P 通过影响 5-羟色胺能系统来影响易患情绪障碍的可能性。
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