神经性贪食症患者大脑中5-羟色胺1A受体结合情况
Brain serotonin 1A receptor binding in bulimia nervosa.
作者信息
Tiihonen Jari, Keski-Rahkonen Anna, Löppönen Mari, Muhonen Maria, Kajander Jaana, Allonen Topias, Någren Kjell, Hietala Jarmo, Rissanen Aila
机构信息
Department of Psychiatry, University Hospital, University of Helsinki, Helsinki, Finland.
出版信息
Biol Psychiatry. 2004 Apr 15;55(8):871-3. doi: 10.1016/j.biopsych.2003.12.016.
BACKGROUND
Selective serotonin reuptake inhibitors (SSRIs) are the first choice for the pharmacologic treatment of bulimia nervosa, but there are no published data on the putative altered serotonin (5-HT) receptor characteristics in patients with bulimia. Experimental studies suggest that the therapeutic antidepressant effect of SSRIs is mediated via 5-HT(1A) receptors. The aim of this study was to measure brain 5-HT(1A) receptor binding among nonmedicated patients with bulimia nervosa.
METHODS
Positron emission tomography (PET) with a selective 5-HT(1A) ligand, [11C]WAY-100635, was performed on eight unmedicated patients with bulimia and 10 healthy comparison subjects.
RESULTS
The binding potential values were greater in patients than in control subjects in all brain regions studied. The most robust differences were observed in the angular gyrus, the medial prefrontal cortex, and the posterior cingulate cortex.
CONCLUSIONS
These results suggest that brain 5-HT(1A) receptor binding is increased in several cortical areas in patients with bulimia nervosa during their state of impulsive binge eating.
背景
选择性5-羟色胺再摄取抑制剂（SSRIs）是神经性贪食症药物治疗的首选，但尚无关于神经性贪食症患者假定的5-羟色胺（5-HT）受体特征改变的已发表数据。实验研究表明，SSRIs的抗抑郁治疗作用是通过5-HT(1A)受体介导的。本研究的目的是测量未接受药物治疗的神经性贪食症患者大脑中5-HT(1A)受体的结合情况。
方法
对8名未接受药物治疗的神经性贪食症患者和10名健康对照者进行了正电子发射断层扫描（PET），使用选择性5-HT(1A)配体[11C]WAY-100635。
结果
在所有研究的脑区中，患者的结合潜能值均高于对照组。在角回、内侧前额叶皮质和后扣带回皮质观察到最显著的差异。
结论
这些结果表明，在神经性贪食症患者冲动性暴饮暴食状态下，其多个皮质区域的大脑5-HT(1A)受体结合增加。
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