Li Jing-Sha, Zhong Jing-Quan, Zeng Qi-Xian, Liu Hong-Zhen, Su Guo-Ying, Zhang Yun
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and Department of Cardiology, Qilu Hospital, Shandong University, Jinan, PR China.
Cardiology. 2011;118(3):147-52. doi: 10.1159/000328016. Epub 2011 May 21.
It was the aim of this study to investigate the effect of ZP123 on prolonged ventricular fibrillation (VF) in swine.
VF was electrically induced in 20 pigs. The animals randomly received either ZP123 or saline control infusion before VF. After 8 min of untreated VF, cardiopulmonary resuscitation and biphasic defibrillation shocks were applied. VF mean frequency (VF(mf)) and mean amplitude (VF(ma)), hemodynamics, outcome of defibrillation and the rate of return of spontaneous circulation (ROSC) were analyzed.
Compared with the control group, VF(mf) was higher but VF(ma) lower during the 8 min of VF in the drug group (11.8 ± 2.1 vs. 10.4 ± 2.0 Hz and 0.24 ± 0.10 vs. 0.31 ± 0.16 mV, respectively; p < 0.05). Hemodynamic variables in the 2 groups were comparable (p > 0.05). The defibrillation threshold was lower and the rate of successful defibrillation was higher in the drug group compared with the control group (92.2 ± 26.4 vs. 133.3 ± 28.9 J and 90 vs. 30%, respectively; p < 0.05). The rate of ROSC was not different between the 2 groups (40 vs. 30%; p > 0.05).
In prolonged VF, ZP123 could decrease the defibrillation threshold and improve the rate of successful defibrillation. However, it could not improve the rate of ROSC - which may be due to its side effect of decreasing VF(ma).
本研究旨在探讨ZP123对猪长时间心室颤动（VF）的影响。
对20头猪进行电诱导VF。在VF发作前，动物随机接受ZP123或生理盐水对照输注。未经治疗的VF持续8分钟后，进行心肺复苏和双相除颤电击。分析VF平均频率（VF(mf)）、平均振幅（VF(ma)）、血流动力学、除颤结果和自主循环恢复率（ROSC）。
与对照组相比，药物组在VF的8分钟内VF(mf)较高但VF(ma)较低（分别为11.8±2.1 vs. 10.4±2.0 Hz和0.24±0.10 vs. 0.31±0.16 mV；p<0.05）。两组的血流动力学变量具有可比性（p>0.05）。与对照组相比，药物组的除颤阈值较低且除颤成功率较高（分别为92.2±26.4 vs. 133.3±28.9 J和90% vs. 30%；p<0.05）。两组之间的ROSC率没有差异（40% vs. 30%；p>0.05）。
在长时间VF中，ZP123可降低除颤阈值并提高除颤成功率。然而，它不能提高ROSC率——这可能是由于其降低VF(ma)的副作用所致。
