Hasan Zaki Noah
Department of Neurology, Al-Kindey College of Medicine, University of Baghdad, Jadiriya Baghdad, Iraq.
South Med J. 2011 May;104(5):319-21. doi: 10.1097/SMJ.0b013e3182114954.
Stroke is one of the major causes of morbidity and mortality throughout the world. Reports about the role of Chlamydia pneumoniae infection in the development of atherosclerosis have been reported in many studies. The aim of the study was to evaluate the association between Chlamydia pneumoniae infection and ischemic stroke.
We evaluated 50 patients with ischemic stroke (32 males and 18 females) and 40 control subjects (22 males and 18 females). They were age- and sex-matched. All enrolled subjects underwent an enzyme-linked immunosorbent assay (ELISA) serologic test for IgG and IgA antibodies for Chlamydia pneumoniae.
Eighteen (36%) patients with ischemic stroke have positive IgA, in comparison with 6 (15%) among the control group (OR 3.18; CI 1.12-9.04; P = 0.03). This translates into the fact that there was a more than three-fold risk of developing ischemic stroke in those with Chlamydia pneumoniae infection compared to those who without. The IgG seropositivity was increased in patients with ischemic stroke, but it did not reach statistical significance (OR = 2.32; CI = 0.97-5.58; P = 0.078).
Chronic Chlamydia pneumoniae infection demonstrated by positive IgA-type antibody can be considered a significant risk for ischemic stroke.
中风是全球发病和死亡的主要原因之一。许多研究报告了肺炎衣原体感染在动脉粥样硬化发展中的作用。本研究的目的是评估肺炎衣原体感染与缺血性中风之间的关联。
我们评估了50例缺血性中风患者（男性32例，女性18例）和40例对照者（男性22例，女性18例）。他们在年龄和性别上相匹配。所有纳入的受试者均接受了针对肺炎衣原体IgG和IgA抗体的酶联免疫吸附测定（ELISA）血清学检测。
18例（36%）缺血性中风患者IgA呈阳性，而对照组中有6例（15%）呈阳性（比值比3.18；可信区间1.12 - 9.04；P = 0.03）。这意味着与未感染肺炎衣原体的人相比，感染肺炎衣原体的人发生缺血性中风的风险增加了三倍多。缺血性中风患者的IgG血清阳性率有所升高，但未达到统计学意义（比值比 = 2.32；可信区间 = 0.97 - 5.58；P = 0.078）。
IgA抗体阳性所显示的慢性肺炎衣原体感染可被视为缺血性中风的一个重要危险因素。
