Hickey Patrick, Stacy Mark
Division of Neurology, Duke University Medical Center, Durham, NC, USA.
Drug Des Devel Ther. 2011;5:241-54. doi: 10.2147/DDDT.S11836. Epub 2011 May 2.
Parkinson's disease is a commonly encountered neurodegenerative disorder primarily found in aged populations. A number of medications are available to control symptoms, although these are less effective in advanced disease. Deep brain stimulation provides a practicable alternative at this stage, although a minority of patients meet the strict criteria for surgery. Novel medications that provide enhanced symptomatic control remain in developmental demand. Both gene and cell-based therapies have shown promise in early clinical studies. A major unmet need is a treatment that slows or stops disease progression.
帕金森病是一种常见的神经退行性疾病,主要见于老年人群。有多种药物可用于控制症状,不过这些药物在疾病晚期效果较差。深部脑刺激在此阶段提供了一种可行的替代方法,尽管只有少数患者符合严格的手术标准。仍需要开发能增强症状控制的新型药物。基因疗法和细胞疗法在早期临床研究中均显示出前景。一个主要的未满足需求是找到一种能减缓或阻止疾病进展的治疗方法。