Radhakrishnan Divya M, Goyal Vinay
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Neurol India. 2018 Mar-Apr;66(Supplement):S26-S35. doi: 10.4103/0028-3886.226451.
Parkinson's disease is a common movement disorder seen in neurological practice, but the diagnosis and management is challenging. The diagnosis is clinical and sometimes difficult, considering a large number of motor and non-motor symptoms in PD patients. The medical management of PD patients is difficult, as choices of drugs are limited and levodopa is the mainstay of treatment. However, levodopa-induced dyskinesia (LID) is commonly seen in Parkinson's disease patients treated with levodopa. This side effect is usually encountered after a long duration of treatment, but occasionally, this may be seen even after a few days or months of treatment. Different types of surgical approaches, including unilateral pallidotomy and deep brain stimulation, have given very good results in PD patients, who cannot be managed by medications alone.
帕金森病是神经科临床常见的运动障碍性疾病,但诊断和管理具有挑战性。诊断主要依靠临床症状,有时会很困难,因为帕金森病患者存在大量运动和非运动症状。帕金森病患者的药物治疗也很困难,因为药物选择有限,左旋多巴是治疗的主要药物。然而,左旋多巴诱发的异动症(LID)在接受左旋多巴治疗的帕金森病患者中很常见。这种副作用通常在长期治疗后出现,但偶尔在治疗几天后或几个月后也可能出现。不同类型的手术方法,包括单侧苍白球切开术和脑深部电刺激术,在仅靠药物无法治疗的帕金森病患者中取得了很好的效果。