间充质干细胞：从基础到临床。
Mesenchymal stem cells: From bench to bedside.
机构信息
Teng Ma, Department of Chemical and Biomedical Engineering, Florida State University, 2525 Pottsdamer Street, Tallahassee, FL 32310, United States.
出版信息
World J Stem Cells. 2010 Apr 26;2(2):13-7. doi: 10.4252/wjsc.v2.i2.13.
Abstract
Human mesenchymal stem cells (hMSCs) have tremendous promise for use in a variety of clinical applications. The ability of these cells to self-renew and differentiate into multiple tissues makes them an attractive cell source for a new generation of cell-based regenerative therapies. Encouraging results from clinical trials have also generated growing enthusiasm regarding MSC therapy and related treatment, but gaps remain in understanding MSC tissue repair mechanisms and in clinical strategies for efficient cell delivery and consistent therapeutic outcomes. For these reasons, discoveries from basic research and their implementation in clinical trials are essential to advance MSC therapy from the laboratory bench to the patient's bedside.
摘要
人骨髓间充质干细胞（hMSCs）在多种临床应用中具有巨大的应用潜力。这些细胞具有自我更新和分化为多种组织的能力，使它们成为新一代基于细胞的再生治疗的有吸引力的细胞来源。临床试验的令人鼓舞的结果也使人们对 MSC 治疗及其相关治疗产生了越来越大的热情，但在理解 MSC 组织修复机制和有效的细胞输送及一致的治疗效果的临床策略方面仍存在差距。出于这些原因，基础研究的发现及其在临床试验中的应用对于将 MSC 治疗从实验室推向患者床边至关重要。
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