Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California, USA.
Mol Med. 2011 Sep-Oct;17(9-10):965-73. doi: 10.2119/molmed.2010.00259. Epub 2011 May 20.
Effective manipulation of human disease processes may be achieved by understanding transcriptional, posttranscriptional and epigenetic events that orchestrate cellular events. The levels of activation of specific molecules, spatial distribution and concentrations of relevant networks of signaling molecules along with the receptiveness of the chromatin to these signals are some of the parameters which dictate context. Effects elicited by the transcription factor signal transducers and activator of transcription 3 (Stat3) are discussed with respect to the context within which Stat3-mediated effects are elicited within the developing and adult mammalian nervous system. Stat3 signals are pivotal to the proliferation and differentiation of neural stem cells. They also participate in neuronal regeneration and cancers of the nervous system. An analysis of the context in which Stat3 activation occurs in these processes provides a potential predictive paradigm with which novel methods for intervention may be designed.
通过理解转录、转录后和表观遗传事件来协调细胞事件，可能实现对人类疾病过程的有效干预。特定分子的激活水平、信号分子相关网络的空间分布和浓度以及染色质对这些信号的敏感性是决定上下文的一些参数。本文讨论了转录因子信号转导和转录激活因子 3（Stat3）的作用，以及 Stat3 介导的作用在发育中和成年哺乳动物神经系统中被引发的背景。Stat3 信号对神经干细胞的增殖和分化至关重要。它们还参与神经元再生和神经系统癌症。对 Stat3 激活在这些过程中发生的背景进行分析，为干预提供了一种潜在的预测范例，可能设计出新的干预方法。
