低剂量率钴远距离治疗作为脑肿瘤的辅助治疗手段

Low-dose rate telecobalt-therapy as a boost against brain-tumors.

作者信息

Yamada S, Takai Y, Nemoto K, Ogawa Y, Hoshi A, Sakamoto K

出版信息

Oncol Rep. 1994 Jan;1(1):191-4.

Abstract

We applied low-dose rate telecobalt therapy (LDRT) as a boost for 26 brain tumors (17 malignant gliomas, 4 pontine gliomas and 5 others). Eleven of those cases were recurrent. The LDRT; 1 Gy per hour, 7 Gy per day, a total dose of 14 Gy in two successive days, was boosted after a conventional irradiation. In malignant glioma, the local control rate and the survival rate were not improved, compared with those of the control group. The treatment results of other brain tumors were also unsatisfactory. The incidence of brain necrosis was higher in the LDRT group. The benefits of the LDRT as a boost for radioresistant brain tumors seem to be small.

摘要

我们采用低剂量率钴远距离治疗（LDRT）作为26例脑肿瘤（17例恶性胶质瘤、4例桥脑胶质瘤和5例其他类型肿瘤）的强化治疗。其中11例为复发病例。LDRT剂量为每小时1 Gy，每天7 Gy，连续两天总剂量达14 Gy，在常规放疗后进行强化治疗。与对照组相比，恶性胶质瘤的局部控制率和生存率并未提高。其他脑肿瘤的治疗效果也不尽人意。LDRT组脑坏死的发生率更高。LDRT作为放射性脑肿瘤强化治疗的益处似乎很小。