Yamada S, Takai Y, Nemoto K, Ogawa Y, Sakamoto K
Department of Radiology, Tohoku University School of Medicine.
Nihon Igaku Hoshasen Gakkai Zasshi. 1991 Dec 25;51(12):1475-80.
The results of treatment of 54 esophageal carcinomas managed with low-dose-rate telecobalt therapy (LDRT) as a boost were compared with those of 89 esophageal carcinomas treated with conventionally fractionated irradiation alone (CFI). The LDRT (1 Gy/hr, 5-7 Gy/day, to a total dose of 14-20 Gy) was boosted about 10 days after the CFI dose of 60 Gy. Although the LDRT group included more advanced cases than the CFI group, local effects and survival rate of the LDRT group, especially those with tumorous X-P and serrated types, were better than those of the CFI group. Late complications were more severe in the LDRT group. However, they were acceptable when the total dose in the LDRT group was brought under 80 Gy.
将54例采用低剂量率远距钴治疗(LDRT)作为加强治疗的食管癌患者的治疗结果,与89例仅接受常规分割照射(CFI)的食管癌患者的治疗结果进行比较。LDRT(1 Gy/小时,5 - 7 Gy/天,总剂量14 - 20 Gy)在CFI剂量60 Gy后约10天进行加强治疗。尽管LDRT组比CFI组包括更多进展期病例,但LDRT组的局部疗效和生存率,尤其是肿瘤呈X-P型和锯齿状类型的患者,优于CFI组。LDRT组的晚期并发症更严重。然而,当LDRT组的总剂量控制在80 Gy以下时,这些并发症是可以接受的。