Noguchi M, Mizukami Y, Kinoshita K, Earashi M, Thomas M, Miyazaki I
KANAZAWA UNIV HOSP,SCH MED,PATHOL SECT,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN.
Oncol Rep. 1994 May;1(3):563-9. doi: 10.3892/or.1.3.563.
We examined epidermal growth factor receptor (EGFR) and/or c-erbB-2 expression, clinicopathological variables, silver-stained nuclear organizer region (Ag-NOR) counts, and their prognostic values in 93 patients with operable breast carcinoma. There was no significant correlation between c-erbB-2 and EGFR expression. Increased Ag-NOR counts were significantly associated with positive c-erbB-2 expression, but not with positive EGFR expression. However, co-expression of both proteins was significantly correlated with axillary lymph node metastases. Significant differences in survival were found between groups of patients stratified by tumor size, histological grade, axillary lymph node metastases, c-erbB-2, and EGFR expression by univariate analysis. In addition, c-erbB-2 and EGFR expression in combination was strongly correlated with decreased survival. However, only axillary lymph node metastases and age appeared to be independent prognostic factors by multivariate analysis. We therefore conclude that the prognostic value of c-erbB-2 and EGFR expression is limited in breast carcinoma.
我们检测了93例可手术乳腺癌患者的表皮生长因子受体（EGFR）和/或c-erbB-2表达、临床病理变量、银染核仁组成区（Ag-NOR）计数及其预后价值。c-erbB-2与EGFR表达之间无显著相关性。Ag-NOR计数增加与c-erbB-2阳性表达显著相关，但与EGFR阳性表达无关。然而，两种蛋白的共表达与腋窝淋巴结转移显著相关。单因素分析显示，根据肿瘤大小、组织学分级、腋窝淋巴结转移、c-erbB-2和EGFR表达分层的患者组之间生存率存在显著差异。此外，c-erbB-2和EGFR联合表达与生存率降低密切相关。然而，多因素分析显示，只有腋窝淋巴结转移和年龄似乎是独立的预后因素。因此，我们得出结论，c-erbB-2和EGFR表达在乳腺癌中的预后价值有限。
