Noguchi M, Thomas M, Kitagawa H, Kinoshita K, Ohta N, Miyazaki I, Mizukami Y
KANAZAWA UNIV HOSP,SCH MED,PATHOL SECT,KANAZAWA 920,JAPAN.
Int J Oncol. 1993 Feb;2(2):203-7. doi: 10.3892/ijo.2.2.203.
We investigated the relationship of argyrophilic nucleolar organizer regions (Ag-NOR) with clinico-pathologic and biologic variables, and its prognostic value in 127 patients with invasive breast carcinoma, Ag-NOR count was found to be significantly correlated with these variables, including DNA ploidy and c-erbB-2 expression. Although Ag-NOR count was a significant prognostic factor in overall and disease-free survival on univariate analysis, it did not appear to be an independent prognostic factor on multivariate analysis, in which status was introduced into the model. In patients in whom regional lymph node dissection has not been performed, however, Ag-NOR count may provide important prognostic information, especially when combined with c-erbB-2 expression.
我们研究了嗜银核仁组织区（Ag-NOR）与127例浸润性乳腺癌患者临床病理及生物学变量的关系及其预后价值。发现Ag-NOR计数与这些变量显著相关，包括DNA倍体和c-erbB-2表达。虽然在单因素分析中Ag-NOR计数是总生存和无病生存的重要预后因素，但在多因素分析（将分期纳入模型）中它似乎不是独立的预后因素。然而，在未进行区域淋巴结清扫的患者中，Ag-NOR计数可能提供重要的预后信息，特别是与c-erbB-2表达相结合时。
