Noguchi M, Earashi M, Ohnishi I, Kitagawa H, Fusida S, Miyazaki I, Mizukami Y
KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,PATHOL SECT,KANAZAWA,ISHIKAWA 920,JAPAN.
Oncol Rep. 1994 Jul;1(4):795-9. doi: 10.3892/or.1.4.795.
We examined the relationship between nm23 expression and clinicopathological variables in 144 patients with invasive breast cancer to assess the role of nm23 expression in estimating prognosis. Expression of nm23 was significantly associated with axillary lymph node (AX) metastases (p=0.0359) and internal mammary lymph node (IMN) metastases (p=0.0146), but not with age, menopausal status, histological type or grade, or tumor size. A univariate study revealed that survival significantly correlated with tumor size, AX and IMN metastases, whereas nm23 expression did not appear to be a significant prognostic factor. Among patients with negative AX, however, survival in patients without nm23 expression was lower than in those with nm23 expression (p=0.0778). Survival in patients with IMN metastases was significantly lower than those without IMN metastases among patients with positive AX (p=0.0073). In a multivariate study, AX and IMN metastases, and nm23 expression appeared to be significant prognostic factors for survival. This study suggests that nm23 expression may be an additional prognostic factor in patients with negative AX, while IMN metastases are an additional prognostic factor in those with positive AX.
我们研究了144例浸润性乳腺癌患者中nm23表达与临床病理变量之间的关系，以评估nm23表达在估计预后中的作用。nm23的表达与腋窝淋巴结（AX）转移（p = 0.0359）和内乳淋巴结（IMN）转移（p = 0.0146）显著相关，但与年龄、绝经状态、组织学类型或分级以及肿瘤大小无关。单因素研究显示，生存率与肿瘤大小、AX和IMN转移显著相关，而nm23表达似乎不是一个显著的预后因素。然而，在AX阴性的患者中，无nm23表达患者的生存率低于有nm23表达的患者（p = 0.0778）。在AX阳性的患者中，有IMN转移患者的生存率显著低于无IMN转移的患者（p = 0.0073）。在多因素研究中，AX和IMN转移以及nm23表达似乎是生存的显著预后因素。本研究表明，nm23表达可能是AX阴性患者的一个额外预后因素，而IMN转移是AX阳性患者的一个额外预后因素。
