Noguchi M, Earashi M, Ohnishi I, Kinoshita K, Thomas M, Fusida S, Miyazaki I, Mizukami Y
KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,PATHOL SECT,KANAZAWA,ISHIKAWA 920,JAPAN.
Oncol Rep. 1994 May;1(3):523-8. doi: 10.3892/or.1.3.523.
We investigated whether nm23 and/or c-erbB-2 expression are useful for estimating the prognosis of invasive breast cancer patients. nm23 expression was significantly correlated with axillary (AX) and internal mammary lymph node (IMN) metastases, whereas c-erbB-2 expression was significantly correlated only with AX metastases. However, a univariate study revealed that survival was correlated significantly with tumor size, AX and IMN metastases, and c-erbB-2 expression, whereas nm23 expression was not an important prognostic factor. In a multivariate study, only AX and IMN metastases were significant prognostic factors. When AX and IMN metastases were excluded from the Cox model, only c-erbB-2 expression had independent prognostic value for survival. Therefore, we conclude that nm23 and/or c-erbB-2 expression may reflect the metastatic potential of breast cancer, but their prognostic value in combination is limited.
我们研究了nm23和/或c-erbB-2表达是否有助于评估浸润性乳腺癌患者的预后。nm23表达与腋窝（AX）及内乳淋巴结（IMN）转移显著相关，而c-erbB-2表达仅与AX转移显著相关。然而，单因素研究显示，生存与肿瘤大小、AX及IMN转移以及c-erbB-2表达显著相关，而nm23表达并非重要的预后因素。在多因素研究中，只有AX及IMN转移是显著的预后因素。当将AX及IMN转移从Cox模型中排除时，只有c-erbB-2表达对生存具有独立的预后价值。因此，我们得出结论，nm23和/或c-erbB-2表达可能反映乳腺癌的转移潜能，但它们联合的预后价值有限。
