Department of Plastic Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Lu, Harbin, People's Republic of China.
Aesthetic Plast Surg. 2012 Feb;36(1):186-92. doi: 10.1007/s00266-011-9751-7. Epub 2011 May 24.
Autologous fat grafting has been regarded as the ideal soft tissue filler for more than a century. Low long-term retention rate and unpredictability limit it from widespread clinical practice. Many theories for this have been proposed: lack of sufficient blood supply and subsequent necrosis is the most accepted. In this pilot study, we showed both macroscopically and microscopically the viability of muscle-derived stem cells (MDSCs) cotransplanted with fat placed intramuscularly for 3 months. MRI scanning showed a stronger fat signal in the MDSC-treated group than that of the control group. Moreover, histological evaluation exhibited well-preserved and intact fat cells in the MDSC-treated group. In contrast, the control group showed extensive fibrosis and fat graft loss. Furthermore, the MDSC-treated group possessed almost threefold greater capillary density than the control group. We conclude that cotransplantation of muscle-derived stem cells and autologous fat tissue improves the long-term survival of intramuscular fat transplants by promoting neovascularization.
自体脂肪移植作为一种理想的软组织填充剂已经有一个多世纪了。但由于长期存活率低且效果不可预测，其临床应用受到限制。为此提出了许多理论：认为缺乏足够的血液供应和随后的坏死是最主要的原因。在这项初步研究中，我们通过宏观和微观两方面展示了将脂肪与肌肉来源的干细胞（MDSCs）共移植到肌肉内 3 个月后的细胞活力。MRI 扫描显示，在 MDSC 治疗组中，脂肪信号比对照组更强。此外，组织学评估显示，MDSC 治疗组的脂肪细胞保存完好且完整，而对照组则表现出广泛的纤维化和脂肪移植物丢失。此外，MDSC 治疗组的毛细血管密度几乎是对照组的三倍。我们得出结论，共移植肌肉来源的干细胞和自体脂肪组织通过促进血管新生，提高了肌肉内脂肪移植的长期存活率。
