癌症-免疫平衡：未解答的问题。
Cancer-immune equilibrium: questions unanswered.
作者信息
Bhatia Alka, Kumar Yashwant
机构信息
PGIMER, Chandigarh, India,
出版信息
Cancer Microenviron. 2011 Aug;4(2):209-17. doi: 10.1007/s12307-011-0065-8. Epub 2011 May 24.
Abstract
Cancer-immune (CI) equilibrium constitutes an important component of the cancer immunoediting theory. It is defined as a period during which our immune system and cancer live in harmony in the body. The immune system, though not able to completely eliminate the cancer, doesn't allow it to progress or metastasize further. Mechanisms of this phase are poorly understood because this phase is difficult to identify even by the most modern detection methods. Till now, the work done on the equilibrium phase of cancer, suggests promising improvements in cancer therapy if the disease could be withheld in this phase. However, there are many queries which remain to be addressed about this interesting yet unresolved phase of cancer immunity.
摘要
癌症-免疫（CI）平衡是癌症免疫编辑理论的一个重要组成部分。它被定义为我们的免疫系统与癌症在体内和谐共存的时期。免疫系统虽然无法完全消除癌症，但也不允许其进一步发展或转移。这个阶段的机制尚不清楚，因为即使采用最现代的检测方法也很难识别这个阶段。到目前为止，对癌症平衡阶段的研究表明，如果能将疾病控制在这个阶段，癌症治疗有望得到改善。然而，关于这个有趣但尚未解决的癌症免疫阶段仍有许多问题有待解决。
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本文引用的文献
1
The capacity of the immune system to control cancer.免疫系统控制癌症的能力。
Eur J Cancer. 2009 Aug;45(12):2068-70. doi: 10.1016/j.ejca.2009.06.002. Epub 2009 Jul 14.
2
EpCAM, a human tumor-associated antigen promotes Th2 development and tumor immune evasion.上皮细胞黏附分子（EpCAM），一种人类肿瘤相关抗原，可促进Th2细胞发育及肿瘤免疫逃逸。
Blood. 2009 Apr 9;113(15):3494-502. doi: 10.1182/blood-2008-08-175109. Epub 2009 Feb 2.
3
Cancer and immune response: old and new evidence for future challenges.癌症与免疫反应：未来挑战的新老证据
Oncologist. 2008 Dec;13(12):1246-54. doi: 10.1634/theoncologist.2008-0166. Epub 2008 Dec 4.
4
Cancer micrometastasis and tumour dormancy.癌症微转移与肿瘤休眠。
APMIS. 2008 Jul-Aug;116(7-8):754-70. doi: 10.1111/j.1600-0463.2008.01033.x.
5
Cellular interactions in the vascular niche: implications in the regulation of tumor dormancy.血管微环境中的细胞相互作用：对肿瘤休眠调节的影响
APMIS. 2008 Jul-Aug;116(7-8):648-59. doi: 10.1111/j.1600-0463.2008.01025.x.
6
Does chemotherapy modify the immune surveillance of hematological malignancies?化疗是否会改变血液系统恶性肿瘤的免疫监视？
Leukemia. 2009 Jan;23(1):53-8. doi: 10.1038/leu.2008.273. Epub 2008 Oct 2.
7
Long-term survival for patients with non-small-cell lung cancer with intratumoral lymphoid structures.具有瘤内淋巴结构的非小细胞肺癌患者的长期生存情况。
J Clin Oncol. 2008 Sep 20;26(27):4410-7. doi: 10.1200/JCO.2007.15.0284.
8
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.阻断血管内皮生长因子受体-3可抑制血管生成芽生和血管网络形成。
Nature. 2008 Jul 31;454(7204):656-60. doi: 10.1038/nature07083. Epub 2008 Jun 25.
9
TNFR1 signaling and IFN-gamma signaling determine whether T cells induce tumor dormancy or promote multistage carcinogenesis.肿瘤坏死因子受体1（TNFR1）信号传导和γ干扰素（IFN-γ）信号传导决定了T细胞是诱导肿瘤休眠还是促进多阶段致癌作用。
Cancer Cell. 2008 Jun;13(6):507-18. doi: 10.1016/j.ccr.2008.04.001.
10
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J Leukoc Biol. 2008 Oct;84(4):988-93. doi: 10.1189/jlb.1107774. Epub 2008 May 30.
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