University of Notre Dame Australia, Fremantle, WA, Australia; Ramsay Healthcare Joondalup Health Campus, Joondalup, WA, Australia.
Psychooncology. 2012 Sep;21(9):970-6. doi: 10.1002/pon.1992. Epub 2011 May 24.
Molar pregnancy is a complication of 1 in 200-2000 pregnancies whereby abnormal placental tissue proliferates in the absence of a fetus and may lead to metastases. The disease origin lies in dispermy or dual fertilisation of the egg. The aim of this study was to explore the impact of molar pregnancy upon the male partner.
Institutional ethics committee approval and individual consent were obtained. All women listed on the state molar pregnancy database who were receiving active follow-up (n = 102) and a random sample of women who had been registered in the previous 30 years (n = 56) were sent a postal survey outlining the purpose of the study and an invitation for their partner to participate. Sixty-six women gave permission for their partner to participate in the study. Questionnaires included the Hospital Anxiety and Depression Scale, Satisfaction with Life Scale and Sexual History Form 12. Responding partners were also invited to make comments about any aspect of particular concern. A reminder mail out was issued after 6 weeks.
The response rate was 62% (N = 41). The key findings were that 32.5% and 12.5% of men met the case criteria for anxiety and depressive disorder, respectively. These figures represent a doubling of usual community rates for anxiety disorder. However, overall quality of life and sexual functioning outcomes were consistent with community samples. The presence of children played a protective role and was associated with significantly better psychological function and quality of life in univariate and multivariate analysis. Qualitative results complemented the quantitative data, with anxiety as the dominant emotional theme.
There are high persisting levels of anxiety in male partners of women with molar pregnancy. Partners may benefit from therapy where anxiety disorders are detected.
葡萄胎是一种妊娠并发症，每 200-2000 次妊娠中就会出现 1 次，异常胎盘组织在没有胎儿的情况下增生，并可能导致转移。该疾病的起源在于卵子的多精受精或双受精。本研究旨在探讨葡萄胎对男性伴侣的影响。
获得机构伦理委员会的批准和个人同意。从国家葡萄胎数据库中列出正在接受主动随访的所有女性（n=102）和前 30 年登记的随机样本女性（n=56）中，寄发了一份邮政调查，概述了研究的目的，并邀请其伴侣参与。66 名女性允许其伴侣参与研究。调查问卷包括医院焦虑和抑郁量表、生活满意度量表和性史表 12。有回应的伴侣还被邀请对任何特别关注的方面发表意见。在 6 周后发出了提醒邮件。
回复率为 62%（N=41）。主要发现是，32.5%和 12.5%的男性分别符合焦虑症和抑郁症的病例标准。这些数字代表了焦虑症在社区中通常发病率的两倍。然而，整体生活质量和性功能结果与社区样本一致。有孩子的存在起着保护作用，并且在单变量和多变量分析中与更好的心理功能和生活质量相关。定性结果补充了定量数据，焦虑是男性伴侣的主要情绪主题。
女性患有葡萄胎的男性伴侣中存在持续高水平的焦虑。如果发现焦虑症，伴侣可能会受益于治疗。
