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用于治疗快速心律失常的射频导管消融术中的皮肤入口剂量:一项多中心研究。

Entrance skin dose during radiofrequency catheter ablation for tachyarrhythmia: a multicenter study.

作者信息

Kidouchi Takashi, Suzuki Shigeru, Furui Shigeru, Mitani Haruo, Nitta Junichi, Matsumoto Kunihiro, Ohtomo Kuni

机构信息

Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

出版信息

Pacing Clin Electrophysiol. 2011 May;34(5):563-70. doi: 10.1111/j.1540-8159.2010.03016.x.

Abstract

BACKGROUND

To assess the entrance skin dose (ESD) during radiofrequency catheter ablation procedures for tachyarrhythmia including atrial fibrillation (Af).

METHODS

This study focused on 99 consecutive patients who underwent procedures for tachyarrhythmia (Af; n = 34, non-Af; n = 65) in three institutions. The non-Af group included atrial flutter, atrial tachycardia, paroxysmal supraventricular tachycardia, ventricular tachycardia, ventricular premature contraction, atrial premature contraction, atrioventricular nodal reentry tachycardia, and Wolff-Parkinson-White syndrome. In two of the three institutions, the procedures were performed for both Af and non-Af. The ESDs were measured using 100 radiosensitive indicators attached to the back of each patient's jacket at 5-cm intervals. For statistical analyses, multiple regression analysis (the dependent variable, Max-ESD; and the independent variables, dose area product [DAP], total fluoroscopic time [TFT], body mass index, etc.), Pearson's correlation test, and the Mann-Whitney test were employed.

RESULTS

The overall averages for the TFTs, the DAPs, and the Max-ESDs were 49.9 ± 28.2 minutes, 71.2 ± 73.7 Gy cm(2) , and 0.57 ± 0.51 Gy, respectively. DAP was positively related to the Max-ESD and was significant in stepwise multiple regression analysis (P < 0.0001). There was a significant association between TFT and Max-ESD in five of the six kinds of angiographic unit, and between DAP and Max-ESD in all three systems with available DAP measures. In one institution, TFT, DAP, and Max-ESD differed significantly between the Af and non-Af groups (P = 0.0002, P < 0.0001, and P < 0.0001).

CONCLUSIONS

During the cardiac catheter ablation, ESDs of only a few patients exceeded the thresholds of radiation skin injuries, and the DAP proved useful to estimate each patient's Max-ESD.

摘要

背景

评估包括心房颤动(Af)在内的快速心律失常射频导管消融手术期间的体表入射剂量(ESD)。

方法

本研究聚焦于三个机构中连续接受快速心律失常手术的99例患者(Af;n = 34,非Af;n = 65)。非Af组包括心房扑动、房性心动过速、阵发性室上性心动过速、室性心动过速、室性早搏、房性早搏、房室结折返性心动过速和预激综合征。在三个机构中的两个,对Af和非Af患者均进行了手术。使用100个放射敏感指标,以5厘米的间隔贴在每位患者夹克背部来测量ESD。进行统计分析时,采用多元回归分析(因变量为最大ESD;自变量为剂量面积乘积[DAP]、总透视时间[TFT]、体重指数等)、Pearson相关检验和Mann-Whitney检验。

结果

TFT、DAP和最大ESD的总体平均值分别为49.9±28.2分钟、71.2±73.7 Gy cm²和0.57±0.51 Gy。DAP与最大ESD呈正相关,在逐步多元回归分析中具有显著性(P < 0.0001)。在六种血管造影设备中的五种中,TFT与最大ESD之间存在显著关联,在所有可获得DAP测量值的三个系统中,DAP与最大ESD之间存在显著关联。在一个机构中,Af组和非Af组之间的TFT、DAP和最大ESD存在显著差异(P = 0.0002,P < 0.0001,P < 0.0001)。

结论

在心脏导管消融过程中,只有少数患者的ESD超过了放射性皮肤损伤的阈值,并且DAP被证明有助于估计每位患者的最大ESD。

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