代谢综合征患者葡萄糖代谢率与脂联素和瘦素血浆水平的关系

[Relationship of glucose metabolic rate and plasma levels of adiponectin and leptin in patients with metabolic syndrome].

作者信息

Ye Jian-hong, Shu Xiao-chun, Chen Ping, Mai Wei-hua, Lang Jiang-ming

机构信息

Department of Endocrinology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou Traditional Chinese Medicine University, Foshan 528000, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2011 Apr 26;91(16):1088-91.

PMID:21609588

Abstract

OBJECTIVE

To investigate the relationship of glucose metabolic rate (GMR) and plasma levels of adiponectin and leptin in patients with metabolic syndrome (MS).

METHODS

A total of 30 MS subjects aged 36-60 years old were selected as MS group. And 20 normal adults were selected as control group. The GMR was evaluated by the technique of hyperinsulinemic euglycemia clamp. The plasma concentrations of adiponectin and leptin were detected by enzyme-linked immunosorbent assay (ELISA). Blood pressure, waist circumference (WC), body weight and body height were measured.

RESULTS

(1) During the steady state (last 30 min), the GMR was significantly lower in MS group than that in control Group [(4.13 ± 1.34) mg×kg(-1)×min(-1) vs (8.33 ± 1.59) mg·kg(-1)×min(-1), P < 0.01]. (2) The plasma level of adiponectin was significantly lower in MS group than that in control group [(5.15 ± 2.54) µg/ml vs (10.28 ± 5.50) µg/ml, P < 0.01]. The plasma level of leptin were significantly higher in MS group than that in control group [(189.37 ± 90.48) ng/ml vs (126.55 ± 72.70) ng/ml, P < 0.01]. (3) In MS group, glucose metabolic rate was associated with WC, BMI, TG, HDL-C FINS, leptin, and adiponectin, (all P < 0.05).

CONCLUSION

The technique of hyperinsulinemic euglycemic clamp shows that the BMR of MS patients significantly decreases. It may be associated with their lowered plasma levels of adiponectin and leptin.

摘要

目的

探讨代谢综合征（MS）患者葡萄糖代谢率（GMR）与血浆脂联素和瘦素水平的关系。

方法

选取30例年龄在36 - 60岁的MS患者作为MS组。选取20例正常成年人作为对照组。采用高胰岛素正常血糖钳夹技术评估GMR。采用酶联免疫吸附测定（ELISA）法检测血浆脂联素和瘦素浓度。测量血压、腰围（WC）、体重和身高。

结果

（1）在稳态期（最后30分钟），MS组的GMR显著低于对照组[（4.13±1.34）mg×kg⁻¹×min⁻¹ 对（8.33±1.59）mg·kg⁻¹×min⁻¹，P < 0.01]。（2）MS组血浆脂联素水平显著低于对照组[（5.15±2.54）μg/ml 对（10.28±5.50）μg/ml，P < 0.01]。MS组血浆瘦素水平显著高于对照组[（189.37±90.48）ng/ml 对（126.55±72.70）ng/ml，P < 0.01]。（3）在MS组中，葡萄糖代谢率与WC、BMI、TG、HDL-C、空腹胰岛素（FINS）、瘦素和脂联素相关（均P < 0.05）。