Liu Bin-Bin, Wang Wei-Hong
Bin-Bin Liu, Wei-Hong Wang, Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China.
World J Clin Oncol. 2011 Mar 10;2(3):164-8. doi: 10.5306/wjco.v2.i3.164.
Pancreatic cancer is estimated to be the fourth most common cancer in men and fifth in women in the world and has poor prognosis. In recent years, more and more effort has been put on the relationship between pancreatic cancer and apoptosis. As a newly discovered inhibitor of apoptosis, survivin has drawn more attention. Strong evidence has shown that survivin is expressed in pancreatic cancer cells on frozen sections. Survivin increases in the development of pancreatic ductal adenocarcinoma and its expression can be a marker in evaluating the prognosis of pancreatic cancer patients. Survivin itself may be a new target in the treatment of pancreatic cancer and a survivin DNA vaccine could generate specific antitumor effects in pancreatic carcinoma models.
据估计，胰腺癌是全球男性中第四大常见癌症，女性中第五大常见癌症，预后较差。近年来，人们越来越关注胰腺癌与细胞凋亡之间的关系。作为一种新发现的细胞凋亡抑制剂，生存素受到了更多关注。有力证据表明，在冰冻切片上，生存素在胰腺癌细胞中表达。在胰腺导管腺癌的发展过程中，生存素水平升高，其表达可作为评估胰腺癌患者预后的一个标志物。生存素本身可能是胰腺癌治疗的一个新靶点，一种生存素DNA疫苗可在胰腺癌模型中产生特异性抗肿瘤作用。
