El-Safadi Samer, Stahl Ulrich, Tinneberg Hans Rudolf, Hackethal Andreas, Muenstedt Karsten
Department of Gynaecology and Obstetrics, University Hospital Giessen and Marburg GmbH, Giessen, Germany.
Case Rep Oncol. 2010 Sep;3(3):451-7. doi: 10.1159/000323003. Epub 2010 Dec 4.
A 24-year-old female patient presented with an extremely rare primary signet cell carcinoma of the right ovary 1 year after surgery for a mucinous borderline tumour of the left ovary. Relaparotomy was carried out with right adnexectomy, appendectomy and partial omentectomy. Surgery was followed by 6 courses of paclitaxel/carboplatinum chemotherapy. After an initial response, the patient again developed increasing ascites. The patient was transferred to our hospital and a re-relaparotomy was carried out, completing the operation. After 3 courses of pegylated doxorubicin/trabectedin, the clinical course showed a positive response and a decline of the tumour marker CEA in peripheral blood. After 5 months, ascites developed in the retroperitoneum so that the chemotherapy had to be changed. In spite of a positive response with the new chemotherapy, the patient died of a very rare pulmonary complication after 1 month within 2 days.
一名24岁女性患者，在左侧卵巢黏液性交界性肿瘤手术后1年，出现极为罕见的右侧卵巢原发性印戒细胞癌。再次剖腹手术，行右侧附件切除术、阑尾切除术和部分大网膜切除术。术后进行了6个疗程的紫杉醇/卡铂化疗。初始治疗有反应后，患者再次出现腹水增多。患者转至我院，再次进行剖腹手术并完成手术。在接受3个疗程的聚乙二醇化阿霉素/曲贝替定治疗后，临床过程显示有阳性反应，外周血肿瘤标志物癌胚抗原（CEA）下降。5个月后，腹膜后出现腹水，因此不得不更换化疗方案。尽管新的化疗方案有阳性反应，但患者在1个月内的2天内死于一种非常罕见的肺部并发症。
