Bork K, Gabbert H, Knop J
Department of Dermatology, University Hospital of Mainz, West Germany.
Arch Dermatol. 1990 Jun;126(6):794-6.
A 30-year-old man is described who since birth had a peculiar symmetrical red-brown micronodular cutaneous plaque. Within the slightly raised plaque, small firm nodules were palpable. Histologic examination revealed phagocytic cells with the appearance of histiocytes between the collagen fibers of the reticular dermis. Immunohistochemical and electron microscopic examination confirmed that the cells of the plaque were dermal dendrocytes with phagocytic activities. The existence of the lesion since birth, the phagocytosis of lipid droplets by the cells, and the lack of associated metabolic disturbances suggest a fat-storing hamartoma of dermal dendrocytes that does not correspond to a known fat-storing or fat-producing tumor.
本文描述了一名30岁男性，自出生以来就有一个特殊的对称性红棕色微小结节性皮肤斑块。在略微隆起的斑块内，可以摸到小而硬的结节。组织学检查显示，在网状真皮的胶原纤维之间有外观类似组织细胞的吞噬细胞。免疫组织化学和电子显微镜检查证实，斑块中的细胞是具有吞噬活性的真皮树突状细胞。自出生以来就存在该病变、细胞对脂滴的吞噬作用以及缺乏相关的代谢紊乱，提示这是一种真皮树突状细胞脂肪储存性错构瘤，与已知的脂肪储存或脂肪生成肿瘤不符。
