Headington J T
University of Michigan, Ann Arbor.
Adv Dermatol. 1986;1:159-71.
In summary, the interstitial cell of the normal human dermis is one of the most highly dendritic cells found in human tissue outside the human brain. There are similar cells found in all collagen-rich tissues, and the morphologic similarities to the normal dendritic osteocyte are unmistakable. Dermal dendrocytes are found to have several cytochemical and immunocytochemical characteristics of cells common to the mononuclear macrophage system. It is likely that dermal dendrocytes are part of an immunologically competent system that is indigenous to the dermis and is either supplementary or complementary to immunologically functional cells of the epidermis. Dermal dendrocytes appear to participate in certain immunologically associated inflammatory dermatoses and are the probable cells of origin for the generic group of fibrous histiocytomas arising in dermis and other collagen-rich tissues.
总之，正常人类真皮中的间质细胞是人类脑组织以外的人体组织中发现的树突最丰富的细胞之一。在所有富含胶原蛋白的组织中都发现了类似的细胞，并且与正常树突状骨细胞的形态相似性是明确无误的。已发现真皮树突状细胞具有单核巨噬细胞系统中常见细胞的几种细胞化学和免疫细胞化学特征。真皮树突状细胞很可能是真皮固有的免疫活性系统的一部分，对表皮的免疫功能细胞起补充或辅助作用。真皮树突状细胞似乎参与某些免疫相关的炎症性皮肤病，并且可能是真皮和其他富含胶原蛋白的组织中发生的纤维组织细胞瘤这一属类肿瘤的起源细胞。
