Wang Wei, Zheng Shan, Shong Zai, Zhao Rui
Department of Surgery, Children's Hospital of Fudan, Shanghai, China.
Fetal Pediatr Pathol. 2011;30(5):301-11. doi: 10.3109/15513815.2011.572959. Epub 2011 May 25.
To explore the possible link between perinatal cytomegalovirus infection and onset of biliary atresia, we build up a perinatal cytomeglovirus induced hepatobiliary system injury model in guinea pigs, verified the biliary tropism of gpCMV and the related inflammatory injury. It suggested host immune status, local response to inflammation, and activation of Th1-cell-mediated antiviral immune responses contributed to newborn geinea pigs' hepatobiliary damage. The model was helpful in study the CMV infection and biliary injury.
为探讨围产期巨细胞病毒感染与胆道闭锁发病之间的可能联系，我们建立了围产期巨细胞病毒诱导的豚鼠肝胆系统损伤模型，验证了豚鼠巨细胞病毒（gpCMV）的胆管嗜性及相关炎症损伤。结果提示宿主免疫状态、对炎症的局部反应以及Th1细胞介导的抗病毒免疫反应的激活导致新生豚鼠肝胆损伤。该模型有助于研究巨细胞病毒感染与胆管损伤。
