Department of Bioresource Engineering, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan.
Phytochemistry. 2011 Aug;72(11-12):1400-5. doi: 10.1016/j.phytochem.2011.04.016. Epub 2011 May 24.
Six isopimarane diterpenes, compounds 1-6, were isolated from the endophytic fungus Paraconiothyrium sp. MY-42. Compound 1 possesses a 19-glucopyranosyloxy group. Its structure was first elucidated by spectroscopic data analysis and finally confirmed by X-ray crystallography, whereas structures 2-6 were mainly elucidated based on the analysis of spectroscopic evidence. Compounds 2 and 3 showed moderate cytotoxicities against the human promyelocytic leukemia cell line HL60 (IC₅₀ 6.7 μM value for 2 and 9.8 μM for 3).
从内生真菌 Paraconiothyrium sp. MY-42 中分离得到 6 种异松烷二萜类化合物，分别为化合物 1-6。化合物 1 含有 19-葡萄糖吡喃氧基。其结构通过光谱数据分析首次阐明，并最终通过 X 射线晶体学确定，而 2-6 的结构主要通过光谱证据分析来阐明。化合物 2 和 3 对人早幼粒细胞白血病细胞系 HL60 表现出中等的细胞毒性（化合物 2 的 IC₅₀ 值为 6.7 μM，化合物 3 的为 9.8 μM）。
