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从银杏叶中分离得到的两个新的银杏内酯。

Two new ginkgolides from the leaves of Ginkgo biloba.

机构信息

College of Pharmacy, Nanjing University of Chinese Medicines, Nanjing, China.

出版信息

Planta Med. 2011 Nov;77(16):1818-21. doi: 10.1055/s-0030-1271153. Epub 2011 May 25.

DOI:10.1055/s-0030-1271153
PMID:21614751
Abstract

Two new diterpenoid compounds, ginkgolide P(1) and ginkgolide Q(2), were isolated from the leaves of Ginkgo biloba L. Their structures were elucidated by various spectroscopic methods, and the structure of 1 was further confirmed by X-ray crystallographic analysis. The activities of the compounds were evaluated against platelet aggregation induced by platelet activating factor (PAF), and the preliminary structure-activity relationship was also discussed.

摘要

从银杏叶中分离得到两个新的二萜化合物，银杏内酯 P（1）和银杏内酯 Q（2）。通过各种光谱方法阐明了它们的结构，并且通过 X 射线晶体学分析进一步确定了 1 的结构。评估了这些化合物对血小板激活因子（PAF）诱导的血小板聚集的活性，并讨论了初步的结构-活性关系。

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