Samulak D, Michalska M, Gaca M, Wilczak M, Mojs E, Chuchracki M
Department of Obstetrics and Gynecology, Regional Hospital in Kalisz, Poland.
Eur J Gynaecol Oncol. 2011;32(2):168-70.
Surgical treatment used in gynecological oncology involves acute postoperative pain which requires efficient treatment. This study covered a group of 128 patients who were randomly divided into two groups. In the postoperative period patients in group I were administered morphine subcutaneously, acetaminophen intravenously and naproxen per rectum. The pain intensity level was checked by means of the pain intensity numeric rating scale (NRS). In the instances of pain rated at 5 or more, patients were additionally administered ketoprofen intravenously. Patients in group II were administered morphine, naproxen, and metamizole instead of acetaminophen and ketoprofen additionally. In group I after the administration of morphine and acetaminophen 22 patients (34.37%) needed additional doses of ketoprofen. In group II 33 women (51.56%) required ketoprofen after the administration of morphine and metamizole (N1 = 22 vs N2 = 33, p < 0.05). The use of metamizol with morphine (without ketoprofen) gave worse analgesic results than acetaminophen with morphine, but the combination of morphine, acetaminophen and ketoprofen or morphine, metamizol and ketoprofen gave satisfactory analgesic results.
妇科肿瘤学中的外科治疗会引发术后剧痛，这需要有效的治疗。本研究涵盖了一组128名患者，他们被随机分为两组。术后，第一组患者接受皮下注射吗啡、静脉注射对乙酰氨基酚以及经直肠给予萘普生。通过疼痛强度数字评定量表（NRS）检查疼痛强度水平。在疼痛评分为5分及以上的情况下，患者还会额外接受静脉注射酮洛芬。第二组患者则接受吗啡、萘普生，另外用安乃近替代对乙酰氨基酚和酮洛芬。在第一组中，给予吗啡和对乙酰氨基酚后，有22名患者（34.37%）需要额外剂量的酮洛芬。在第二组中，33名女性（51.56%）在给予吗啡和安乃近后需要酮洛芬（N1 = 22对N2 = 33，p < 0.05）。安乃近与吗啡联用（不使用酮洛芬）的镇痛效果比对乙酰氨基酚与吗啡联用更差，但吗啡、对乙酰氨基酚和酮洛芬联用或吗啡、安乃近和酮洛芬联用能产生令人满意的镇痛效果。
