Rastogi S K, Gupta B N, Mathur N, Husain T, Mahendra P N
Epidemiology Division, Industrial Toxicology Research Centre, Lucknow, India.
Toxicol Ind Health. 1990 Jan;6(1):145-54. doi: 10.1177/074823379000600109.
This paper reports a cross-sectional study of a non-smoking population of silica exposed female workers compared with a group of healthy non-exposed females. The exposed group is divided into cohorts according to the presence or absence of pneumoconiosis in either simple or complex form. The study revealed statistically significant difference in pulmonary function between each of the pneumoconiosis group and the controls and healthy exposed workers. Furthermore, there was statistically significant difference between the values of pulmonary function parameters of the healthy exposed group and the controls. The most important observation of the study is that almost equal decrement of pulmonary function values was observed in the diseased groups and in the healthy exposed group compared to the decrement seen between the latter group and the control group. VC and FVC showed a mean fall of 11.0 and 11.5% in the healthy exposed group as compared to those observed in the unexposed controls (p less than 0.01 and p less than 0.05) while in the pneumoconiosis group VC and FVC showed 16.9 and 18.2% decrease as compared with the values obtained in the healthy grinders (p less than 0.01). Similarly FEV1 showed almost same decrease in the healthy (17.9%) and diseased (20.7%) exposed groups (p less than 0.001). However, FEV0.75 and MVV parameters showed greater decrement (25.4 and 33.7%) in the pneumoconiosis group as compared to 15.7 and 18.5% observed in the healthy exposed workers. The important observation made in this study is that potential pulmonary debilitation may occur in pneumoconiosis before, or in the absence of, any radiologic findings.
本文报告了一项横断面研究，该研究将接触二氧化硅的非吸烟女性工人人群与一组健康的未接触女性进行了比较。根据是否存在单纯或复杂形式的尘肺病，将接触组分为不同队列。研究显示，每个尘肺病组与对照组及健康接触工人之间在肺功能方面存在统计学上的显著差异。此外，健康接触组与对照组的肺功能参数值之间也存在统计学上的显著差异。该研究最重要的观察结果是，与后一组和对照组之间的下降相比，患病组和健康接触组的肺功能值下降几乎相同。与未接触对照组相比，健康接触组的肺活量（VC）和用力肺活量（FVC）平均下降了11.0%和11.5%（p<0.01和p<0.05），而在尘肺病组中，VC和FVC与健康研磨工人相比下降了16.9%和18.2%（p<0.01）。同样，第一秒用力呼气容积（FEV1）在健康（17.9%）和患病（20.7%）接触组中的下降几乎相同（p<0.001）。然而，与健康接触工人中观察到的15.7%和18.5%相比，尘肺病组的FEV0.75和最大通气量（MVV）参数下降幅度更大（25.4%和33.7%）。该研究的重要观察结果是，在尘肺病中，在出现任何放射学表现之前或没有放射学表现的情况下，可能会发生潜在的肺功能衰弱。
