Department of Medical Biotechnology, College of Medical Science, Soonchunhyang University, Asan, Korea
BMB Rep. 2011 May;44(5):291-7. doi: 10.5483/BMBRep.2011.44.5.291.
Aging is one of the most complicated biological processes in all species. A number of different model organisms from yeast to monkeys have been studied to understand the aging process. Until recently, many different age-related genes and age-regulating cellular pathways, such as insulin/IGF-1-like signal, mitochondrial dysfunction, Sir2 pathway, have been identified through classical genetic studies. Parallel to genetic approaches, genome-wide approaches have provided valuable insights for the understanding of molecular mechanisms occurring during aging. Gene expression profiling analysis can measure the transcriptional alteration of multiple genes in a genome simultaneously and is widely used to elucidate the mechanisms of complex biological pathways. Here, current global gene expression profiling studies on normal aging and age-related genetic/environmental interventions in widely-used model organisms are briefly reviewed.
衰老是所有物种中最复杂的生物过程之一。为了了解衰老过程，人们已经研究了从酵母到猴子的许多不同的模式生物。直到最近，通过经典的遗传学研究，已经确定了许多不同的与年龄相关的基因和调节细胞途径，如胰岛素/ IGF-1 样信号、线粒体功能障碍、Sir2 途径等。与遗传方法并行的是，全基因组方法为理解衰老过程中发生的分子机制提供了有价值的见解。基因表达谱分析可以同时测量基因组中多个基因的转录变化，广泛用于阐明复杂生物学途径的机制。在这里，简要回顾了广泛使用的模式生物中正常衰老和与年龄相关的遗传/环境干预的当前全基因组基因表达谱研究。
