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Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus.

作者信息

Smith P F, Darlington C L, Hubbard J I

机构信息

Department of Psychology, University of Otago, Dunedin, New Zealand.

出版信息

Brain Res. 1990 Apr 9;513(1):149-51. doi: 10.1016/0006-8993(90)91101-l.

DOI:10.1016/0006-8993(90)91101-l
PMID:2161695
Abstract

Single medial vestibular nucleus neurons were recorded from guinea pig brainstem slices in vitro while superfusing with the selective N-methyl-D-aspartate (NMDA) antagonists, MK801 and CPP. The majority of neurons tested showed a decrease in firing rate in response to these NMDA antagonists, suggesting that NMDA receptors may contribute to the resting activity of MVN neurons.

摘要

相似文献

1
Evidence that NMDA receptors contribute to synaptic function in the guinea pig medial vestibular nucleus.
Brain Res. 1990 Apr 9;513(1):149-51. doi: 10.1016/0006-8993(90)91101-l.
2
Comparison of the effects of NMDA antagonists on medial vestibular nucleus neurons in brainstem slices from labyrinthine-intact and chronically labyrinthectomized guinea pigs.NMDA拮抗剂对完整迷路和慢性迷路切除豚鼠脑干切片内侧前庭核神经元作用的比较。
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Effects of NMDA antagonists, MK-801 and CPP, upon local cerebral glucose use.NMDA拮抗剂MK-801和CPP对局部脑葡萄糖利用的影响。
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NMDA receptor antagonists CPP and MK-801 partially suppress the epileptiform discharges induced by the convulsant drug bicuculline in the rat neocortex.
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引用本文的文献

1
Synaptic plasticity in medial vestibular nucleus neurons: comparison with computational requirements of VOR adaptation.内侧前庭核神经元的突触可塑性:与 VOR 适应的计算要求比较。
PLoS One. 2010 Oct 5;5(10):e13182. doi: 10.1371/journal.pone.0013182.
2
Medial vestibular neurons are endogenous pacemakers whose discharge is modulated by neurotransmitters.内侧前庭神经元是内源性起搏器,其放电受神经递质调节。
Cell Mol Neurobiol. 1993 Dec;13(6):601-13. doi: 10.1007/BF00711560.
3
Ionic conductances contributing to spike repolarization and after-potentials in rat medial vestibular nucleus neurones.
对大鼠内侧前庭核神经元动作电位复极化和后电位有贡献的离子电导。
J Physiol. 1994 Nov 15;481 ( Pt 1)(Pt 1):61-77. doi: 10.1113/jphysiol.1994.sp020419.
4
Guinea pig medial vestibular nucleus neurons in vitro respond to ACTH4-10 at picomolar concentrations.豚鼠内侧前庭核神经元在体外对皮摩尔浓度的促肾上腺皮质激素4-10有反应。
Exp Brain Res. 1990;82(3):637-40. doi: 10.1007/BF00228805.
5
Excitatory amino acid receptors in normal and abnormal vestibular function.正常和异常前庭功能中的兴奋性氨基酸受体
Mol Neurobiol. 1991;5(2-4):369-87. doi: 10.1007/BF02935559.
6
Tonic activity of rat medial vestibular nucleus neurones in vitro and its inhibition by GABA.大鼠内侧前庭核神经元的体外紧张性活动及其受γ-氨基丁酸的抑制作用
Exp Brain Res. 1992;88(3):466-72. doi: 10.1007/BF00228176.
7
NMDA receptor-mediated long term modulation of electrically evoked field potentials in the rat medial vestibular nuclei.
Exp Brain Res. 1992;90(3):546-50. doi: 10.1007/BF00230937.
8
Medial vestibular nucleus in the guinea-pig: NMDA-induced oscillations.豚鼠内侧前庭核:NMDA诱导的振荡。
Exp Brain Res. 1992;88(1):187-92. doi: 10.1007/BF02259140.