豚鼠内侧前庭核神经元在体外对皮摩尔浓度的促肾上腺皮质激素4-10有反应。

Guinea pig medial vestibular nucleus neurons in vitro respond to ACTH4-10 at picomolar concentrations.

作者信息

Darlington C L, Smith P F, Hubbard J I

机构信息

Department of Physiology, University of Otago, Dunedin, New Zealand.

出版信息

Exp Brain Res. 1990;82(3):637-40. doi: 10.1007/BF00228805.

DOI:10.1007/BF00228805

PMID:1963409

Abstract

The responses of single guinea pig medial vestibular nucleus (MVN) neurons in vitro to adrenocorticotropic hormone, fragment 4-10 (ACTH4-10) were recorded extracellularly. In coronal slices and in the isolated MVN, neurons were found which responded to ACTH4-10 at picomolar concentrations (10(-12)M), indicating that ACTH4-10 acts directly on MVN neurons and suggesting the possibility that ACTH4-10 may act as a neurotransmitter in the MVN. In most cases where neurons responded to ACTH4-10 (37/74 neurons), the effect was a decrease in firing. Whether or not the depressive action of ACTH4-10 on the firing rate of MVN neurons in vitro is related to the acceleration of behavioral recovery from unilateral labyrinthectomy (vestibular compensation), which has been reported previously (Flohr and Luneburg 1982; Igarashi et al. 1985), is unclear.

摘要

对豚鼠单个内侧前庭核（MVN）神经元在体外对促肾上腺皮质激素片段4 - 10（ACTH4 - 10）的反应进行了细胞外记录。在冠状切片和分离的MVN中，发现有神经元对皮摩尔浓度（10⁻¹²M）的ACTH4 - 10有反应，这表明ACTH4 - 10直接作用于MVN神经元，并提示ACTH4 - 10可能在MVN中作为一种神经递质发挥作用。在大多数神经元对ACTH4 - 10有反应的情况下（74个神经元中的37个），其作用是放电减少。ACTH4 - 10对体外MVN神经元放电率的抑制作用是否与先前报道的单侧迷路切除术后行为恢复加速（前庭代偿）有关（Flohr和Luneburg，1982年；Igarashi等人，1985年）尚不清楚。