Decker M W, Gill T M, McGaugh J L
Department of Psychobiology, University of California, Irvine 92717.
Brain Res. 1990 Apr 9;513(1):81-5. doi: 10.1016/0006-8993(90)91091-t.
These experiments examined the effects of separate and concurrent muscarinic cholinergic and beta-adrenergic blockade on inhibitory (passive) avoidance performance and spatial learning in the Morris water maze. Pretraining systemic administration of either scopolamine (0.3 or 1.0 mg/kg) or propranolol (3.0 or 10.0 mg/kg) had no significant effect on one-day retention of step-through inhibitory avoidance training. Similarly, pretraining administration of either 0.3 mg/kg scopolamine or 10 mg/kg propranolol did not affect spatial learning in the Morris water maze. However, combined administration of scopolamine and 10.0 mg/kg of propranolol impaired performance on these tasks. These findings further support a role for interactions between norepinephrine and acetylcholine in the modulation of learning and memory and implicate the participation of beta-adrenergic mechanisms in this interaction. Because cholinergic and noradrenergic deterioration is found in aging and Alzheimer's disease, these results also have implications regarding the role of age-related noradrenergic and cholinergic dysfunction in cognitive decline.
这些实验研究了毒蕈碱型胆碱能和β-肾上腺素能阻断单独及同时作用对Morris水迷宫中抑制性（被动）回避行为表现和空间学习的影响。在进行穿梭箱抑制性回避训练前，全身给予东莨菪碱（0.3或1.0mg/kg）或普萘洛尔（3.0或10.0mg/kg）对一天后的记忆保持没有显著影响。同样，在进行Morris水迷宫空间学习前给予0.3mg/kg东莨菪碱或10mg/kg普萘洛尔也不影响空间学习。然而，联合给予东莨菪碱和10.0mg/kg普萘洛尔会损害这些任务的行为表现。这些发现进一步支持了去甲肾上腺素和乙酰胆碱之间的相互作用在学习和记忆调节中的作用，并表明β-肾上腺素能机制参与了这种相互作用。由于在衰老和阿尔茨海默病中发现胆碱能和去甲肾上腺素能功能退化，这些结果也对年龄相关的去甲肾上腺素能和胆碱能功能障碍在认知衰退中的作用具有启示意义。
