Kim Hyun Soo, Lee Jae Jin, Cho Ah Rang, Kim Dae Hyun, Choi Cheon Woong
Department of Medical Oncology and Hematology, East-West Neo Medical Center, Kyung Hee University, Seoul, Republic of Korea.
J Pediatr Hematol Oncol. 2011 Jul;33(5):e216-9. doi: 10.1097/MPH.0b013e318211836a.
Primary bronchogenic carcinoma of the lung is extremely rare in childhood, particularly the squamous cell type. Only 13 cases have been reported in the literature. We report a case of squamous cell carcinoma in an autistic, 16-year-old boy who presented with a productive cough. Interestingly, he was a never-smoker, but had been exposed to environmental tobacco smoking by his father for 13 years. The diagnosis was delayed by approximately 1 month due to his young age. He was diagnosed with squamous cell carcinoma of the lung by video-assisted thoracoscopic surgery, and chemotherapy was arranged. Considering his age, autism, and good performance status, a combined chemotherapeutic regimen with gemcitabine plus carboplatin was planned. After the second cycle of chemotherapy, the cough resolved and a computed tomography scan showed a partial response of the central conglomerated mass with the absence of the malignant pleural effusion.
原发性支气管肺癌在儿童时期极为罕见，尤其是鳞状细胞类型。文献中仅报道过13例。我们报告一例16岁患自闭症男孩的鳞状细胞癌病例，该男孩表现为咳痰性咳嗽。有趣的是，他从不吸烟，但因父亲吸烟使他有13年的环境烟草暴露史。由于他年龄小，诊断延迟了约1个月。通过电视辅助胸腔镜手术，他被诊断为肺鳞状细胞癌，并安排了化疗。考虑到他的年龄、自闭症以及良好的身体状况，计划采用吉西他滨加卡铂的联合化疗方案。化疗第二个周期后，咳嗽缓解，计算机断层扫描显示中央聚集性肿块部分缓解，且无恶性胸腔积液。
