Geddes J W, Cahan L D, Cooper S M, Kim R C, Choi B H, Cotman C W
Division of Neurosurgery, University of California, Irvine 92717.
Exp Neurol. 1990 Jun;108(3):214-20. doi: 10.1016/0014-4886(90)90125-c.
In temporal lobe epilepsy, excitatory amino acid receptors in the hippocampus and temporal lobe may contribute to both increased excitability and vulnerability to excitotoxic damage. We used receptor autoradiography to examine the density of N-methyl-D-aspartate (NMDA) and kainic acid (KA) receptors in the hippocampus and parahippocampal gyrus obtained from five patients who had undergone anterior temporal lobectomy for the treatment of intractable seizures and from six control individuals, in which the hippocampus was obtained postmortem. Within the hippocampal formation, loss of [3H]KA and NMDA-sensitive L-[3H]glutamate binding was apparent in the sclerotic regions CA3, hilus, and CA1. In the subiculum and molecular layer of the denate gyrus, binding densities were maintained or even increased in some of the epileptic patients. A two-fold increase in L-[3H]glutamate binding, along with an increase in [3H]KA binding, was observed in the parahippocampal gyrus obtained from the epileptic patients. The results suggest that the vulnerability of the hippocampus in temporal lobe epilepsy may result, at least in part, from the presence of aberrant excitatory circuits in the parahippocampal gyrus.
在颞叶癫痫中，海马体和颞叶中的兴奋性氨基酸受体可能导致兴奋性增加以及对兴奋性毒性损伤的易感性增加。我们使用受体放射自显影技术，检测了五例因治疗顽固性癫痫接受前颞叶切除术患者以及六例死后获取海马体的对照个体的海马体和海马旁回中N-甲基-D-天冬氨酸（NMDA）和 kainic 酸（KA）受体的密度。在海马结构内，硬化区域CA3、齿状回门和CA1中[3H]KA和NMDA敏感的L-[3H]谷氨酸结合明显丧失。在一些癫痫患者的齿状回下托和分子层中，结合密度保持不变甚至增加。在癫痫患者的海马旁回中观察到L-[3H]谷氨酸结合增加两倍，同时[3H]KA结合也增加。结果表明，颞叶癫痫中海马体的易感性可能至少部分源于海马旁回中异常兴奋性回路的存在。
