Geddes J W, Cotman C W
Neurosci Res. 1986 Sep;3(6):672-8. doi: 10.1016/0168-0102(86)90062-3.
Entorhinal cell loss occurs in the course of Alzheimer's disease. In rodents, entorhinal lesions result in axon sprouting in the hippocampus. Quantitative autoradiography was used to examine the density and distribution of N-methyl-D-aspartate (NMDA) and kainic acid (KA) receptors in human hippocampus obtained post-mortem from Alzheimer's disease patients and from age-matched controls. In Alzheimer's disease, there was an expanded distribution of the KA receptor field in the dentate gyrus, indicative of sprouting of the commissural and associational fibers. This regenerative response is thought to facilitate transmission, but in doing so it may also enhance vulnerability to excitotoxic mediated neuronal damage. No significant change was observed in the density or distribution of NMDA receptors. The distribution of these receptors does, however, correlate with the predilection for neurofibrillary tangles and neuritic plaques in hippocampal subfields.
内嗅细胞缺失发生在阿尔茨海默病的病程中。在啮齿动物中，内嗅损伤会导致海马体轴突发芽。采用定量放射自显影术检查了从阿尔茨海默病患者和年龄匹配的对照者死后获取的人类海马体中N-甲基-D-天冬氨酸（NMDA）和海人酸（KA）受体的密度和分布。在阿尔茨海默病中，齿状回中KA受体场的分布扩大，表明连合纤维和联合纤维发生了发芽。这种再生反应被认为有助于传递，但这样做也可能增加对兴奋性毒性介导的神经元损伤的易感性。未观察到NMDA受体的密度或分布有显著变化。然而，这些受体的分布确实与海马亚区神经原纤维缠结和神经炎性斑块的偏好相关。
