Nazik Hasan, Bektöre Bayhan, Öngen Betigül, Özyurt Mustafa, Baylan Orhan, Haznedaroğlu Tunçer
Istanbul University, Istanbul Medical Faculty, Department of Microbiology and Clinical Microbiology, Istanbul, Turkey.
New Microbiol. 2011 Apr;34(2):225-8. Epub 2011 Apr 30.
An extended-spectrum B-lactamase (ESBL)-producing Providencia stuartii isolate was studied. A qnrA1 gene co-expressing blaVEB-1 gene was detected. Both genes were transferred to the recipient strain. The ciprofloxacin MIC of recipient strain increased tenfold. The blaVEB-1 gene persisted in microorganisms in Turkey but it also spread with PMQR genes to other species. The combination of PMQR with multidrug resistant isolates producing ESBLs may compromise the use of valuable antibiotics. Serious efforts are necessary to detect PMQR determinants not only with common B-lactamases in widespread pathogens but also with uncommon forms that are encountered infrequently.
对一株产超广谱β-内酰胺酶（ESBL）的斯氏普罗威登斯菌分离株进行了研究。检测到一个共表达blaVEB-1基因的qnrA1基因。这两个基因都转移到了受体菌株中。受体菌株的环丙沙星最低抑菌浓度（MIC）增加了10倍。blaVEB-1基因在土耳其的微生物中持续存在，但它也与质粒介导的喹诺酮类耐药（PMQR）基因一起传播到其他物种。PMQR与产ESBLs的多重耐药分离株的组合可能会影响有价值抗生素的使用。不仅要在广泛传播的病原体中检测常见β-内酰胺酶的PMQR决定簇，还要检测很少遇到的罕见形式，这需要付出巨大努力。
