与甲型病毒性肝炎相关的一种抗原（博特夫格勒抗原）的形态学和物理特性

Morphological and physical characteristics of an antigen associated with viral hepatitis type A (Botevgrad antigen).

作者信息

Teoharova M, Karabasheva V, Mineva E, Losev B, Andonov A

出版信息

Zentralbl Bakteriol Orig A. 1978 Nov;242(2):156-67.

Abstract

Immune electron microscopy (IEM) was employed in studying faecal samples of viral hepatitis type A patients and their contacts, in whom the presence of an antigen, differing from the HBsAg, designated as Botevgrad antigen (BA) was proved by the CFT. Particles 25--28 nm in diameter, aggregated by sera positive for the anti-HAAg were established in the faecal samples. The buoyant density of these particles in CsCl was found to be 1.40 g/ml. Particles of the same buoyant density were established also in sera positive for BA which were aggregated in large masses with antiserum against BA obtained from rabbits. The associations between BA and HAAg are discussed.

摘要

采用免疫电子显微镜（IEM）研究甲型病毒性肝炎患者及其接触者的粪便样本，通过补体结合试验（CFT）证实其中存在一种不同于乙肝表面抗原（HBsAg）的抗原，命名为博特夫格勒德抗原（BA）。在粪便样本中发现了直径为25 - 28纳米的颗粒，这些颗粒被抗甲型肝炎抗原（HAAg）阳性血清所凝集。这些颗粒在氯化铯中的浮密度为1.40克/毫升。在BA阳性血清中也发现了具有相同浮密度的颗粒，这些颗粒与从兔获得的抗BA抗血清大量聚集。文中讨论了BA与HAAg之间的关联。